Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19

The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 ye...

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Veröffentlicht in:	Inflammation research 2023-05, Vol.72 (5), p.929-932
Hauptverfasser:	Arifa, Raquel Duque Nascimento, Gonçalves-Pereira, Marcela Helena, Santiago, Luciana, Ravetti, Cecilia Gómez, Vassallo, Paula Frizera, de Fátima Souza Oliveira, Fernanda, de Paula Sabino, Adriano, Teixeira, Mauro Martins, Nobre, Vandack, da Costa Santiago, Helton, Souza, Daniele G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Allergology Alveoli Biomedical and Life Sciences Biomedicine Blood levels Bronchoalveolar Lavage Fluid Bronchus COVID-19 Cytokines Dermatology Flow cytometry Humans Immunology Inflammation Interleukin 10 Lavage Leukocytes (neutrophilic) Lung Lungs Medical prognosis Mortality Neurology Neutrophils Original Research Paper Pharmacology/Toxicology Prognosis R&D Research & development Rheumatology Survival analysis Ventilators
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Zusammenfassung:	The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 years). In addition, we have shown that older patients have higher serum concentration of CXCL8 and increased IL-10 expression by neutrophils.
ISSN:	1023-3830 1420-908X
DOI:	10.1007/s00011-023-01726-y