Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus

A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism of the removal is thought to be due to cross reactivity of anti-dsDNA with dextran sulp...

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Veröffentlicht in:	Annals of the rheumatic diseases 1989-10, Vol.48 (10), p.856-860
Hauptverfasser:	Kinoshita, M, Aotsuka, S, Funahashi, T, Tani, N, Yokohari, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Antinuclear - analysis Biological and medical sciences Complement C3 - analysis Dextran Sulfate Dextrans - immunology DNA - analysis Humans Immunoglobulin G - analysis Immunoglobulin M - analysis Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - therapy Male Medical sciences Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Zusammenfassung:	A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism of the removal is thought to be due to cross reactivity of anti-dsDNA with dextran sulphate, which has negatively charged units. Selective removal of anti-dsDNA is expected to contribute not only to the treatment but also to elucidation of the pathogenesis of SLE.
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.48.10.856