Sodium aurothiomalate does not block interleukin 1 production in rabbits

Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by...

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Veröffentlicht in:	Annals of the rheumatic diseases 1988-06, Vol.47 (6), p.506-508
Hauptverfasser:	Zurovsky, Y, Laburn, H P, Mitchell, D, Ruck, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Female Fever - drug therapy Gold Sodium Thiomalate - pharmacology Gold Sodium Thiomalate - therapeutic use Interleukin-1 - biosynthesis Male Medical sciences Monocytes - drug effects Monocytes - metabolism Pharmacology. Drug treatments Rabbits
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Zusammenfassung:	Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.47.6.506