Regulation of the MyD88 gene in chicken spleen inflammation induced by stress

Abstract In order to investigate the regulatory role of the myeloid differentiation factor 88 (MyD88) gene in the stress inflammatory response to chicken spleen, the chicken stress model and macrophage (HD11) inflammation model were constructed in this study. Enzyme-linked immunosorbent assay and qu...

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Veröffentlicht in:	Journal of animal science 2023-01, Vol.101
Hauptverfasser:	Ding, Mengxia, Yu, Yange, Zhu, Zhaoyan, Tian, Huihui, Guo, Yujie, Zan, Ruilong, Tian, Yadong, Jiang, Ruirui, Li, Kui, Sun, Guirong, Han, Ruili, Li, Donghua, Kang, Xiangtao, Yan, Fengbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD3 antigen CD4 antigen Cell and Molecular Biology Chickens Chickens - genetics Chickens - metabolism Enzyme-linked immunosorbent assay Gene expression Heat stress Heat tolerance IL-1β Immunoglobulin G Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - veterinary Inflammatory response Interleukins Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Myeloid Differentiation Factor 88 - pharmacology NF-kappa B - genetics NF-κB protein Poultry Signal Transduction Spleen Spleen - metabolism Stress, Physiological Synergistic effect Temperature effects TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Trimming Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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Zusammenfassung:	Abstract In order to investigate the regulatory role of the myeloid differentiation factor 88 (MyD88) gene in the stress inflammatory response to chicken spleen, the chicken stress model and macrophage (HD11) inflammation model were constructed in this study. Enzyme-linked immunosorbent assay and quantitative real-time PCR were used to investigate the effects of MyD88 on immune and inflammatory indicators. The results demonstrated that the levels of IgG, CD3+ and CD4+ in the serum of chickens in the beak trimming stress and heat stress groups decreased significantly compared to the control group without stress (P
ISSN:	0021-8812 1525-3163
DOI:	10.1093/jas/skad060