CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis

This study aims to analyze the regulatory non-coding RNAs in the pathological process of tuberculosis (TB), and identify novel diagnostic biomarkers. A longitudinal study was conducted in 5 newly diagnosed pulmonary tuberculosis patients, peripheral blood samples were collected before and after anti...

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Veröffentlicht in:	Medicine (Baltimore) 2023-03, Vol.102 (11), p.e33117-e33117
Hauptverfasser:	Song, Jie, Sun, Jiaguan, Wang, Yuqing, Ding, Yuehe, Zhang, Shengrong, Ma, Xiuzhen, Chang, Fengxia, Fan, Bingdong, Liu, Hongjuan, Bao, Chenglan, Meng, Weimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Female Gene Regulatory Networks Humans Longitudinal Studies MicroRNAs - genetics MicroRNAs - metabolism Observational Study RNA, Long Noncoding - genetics RNA, Messenger - genetics Tuberculosis - diagnosis Tuberculosis - genetics
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Beschreibung
Zusammenfassung:	This study aims to analyze the regulatory non-coding RNAs in the pathological process of tuberculosis (TB), and identify novel diagnostic biomarkers. A longitudinal study was conducted in 5 newly diagnosed pulmonary tuberculosis patients, peripheral blood samples were collected before and after anti-TB treatment for 6 months, separately. After whole transcriptome sequencing, the differentially expressed RNAs (DE RNAs) were filtrated with \|log2 (fold change) \| > log2(1.5) and P value
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000033117