Long–Term Effect on Blood Pressure of Early Brief Treatment by Different Antihypertensive Agents: A Study in the Prague Hypertensive Rat

In the Prague hypertensive rat (PHR), a strain of genetic hypertension derived from Wistar, administration of various antihypertensive drugs (AHD) during the developmental phase of hypertension (weeks 5–9 of life) prevents the rise of blood pressure. However, only drugs blocking the renin–angiotensin system (RAS, i.e. AT1–antagonist losartan and ACE inhibitor perindopril) have a long–term effect on blood pressure leading to values of systolic blood pressure (SBP) of 174.5±14.5 and 169.8±15.3 mmHg, respectively, at week 30. At this time, control, untreated PHR have a SBP of 222.0±16.6 mmHg (p