Anti-Inflammatory Effect of Interleukin-10 in Rabbit Immune Complex-Induced Colitis

Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine that downregulates the secretion of pro-inflammatory cytokines and additionally induces the secretion of anti-inflammatory cytokines, thus possibly leading to reduction of chronic inflammation in inflammatory bowel disease. In this...

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Veröffentlicht in:	Scandinavian journal of gastroenterology 1998, Vol.33 (7), p.754-758
Hauptverfasser:	GROOL, T. A, VAN DULLEMEN, H, MEENAN, J, KOSTER, F, TEN KATE, F. J. W, LEBEAUT, A, TYTGAT, G. N. J, VAN DEVENTER, S. J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antigen-Antibody Complex Biological and medical sciences Disease Models, Animal Dose-Response Relationship, Drug Down-Regulation Enterocolitis - chemically induced Enterocolitis - drug therapy Enterocolitis - immunology Enterocolitis - pathology Gastroenterology. Liver. Pancreas. Abdomen Interleukin-10 - pharmacology Interleukin-10 - physiology Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - pathology Leukotriene B4 - analysis Male Medical sciences Other diseases. Semiology Rabbits Random Allocation Reference Values Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Zusammenfassung:	Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine that downregulates the secretion of pro-inflammatory cytokines and additionally induces the secretion of anti-inflammatory cytokines, thus possibly leading to reduction of chronic inflammation in inflammatory bowel disease. In this study we evaluated the anti-inflammatory effect of IL-10 in a model of acute colitis in rabbits. Methods
ISSN:	0036-5521 1502-7708
DOI:	10.1080/00365529850171710