HpaII Polymerase Chain Reaction Restriction Fragment Length Polymorphism in the Human CD19 Gene on 16p11

Sorry, there is no abstract. Read the first few lines of the text instead! The CD19 is a 95-kD transmembrane pan-B lymphocyte marker. It serves as a cell surface response regulator that establishes signaling thresholds critical for B lymphocyte development, activation and proliferation. CD19 enhances membrane IgM signaling and is required for B lymphocyte antibody responses to T-dependent antigens . Polymerase chain reaction (PCR) restriction fragment length polymorphism analysis revealed a polymorphic site in exon 4 of CD19 at proline 235, without changing the amino acid with an observed heterozygosity of 0.42. Thus the biological significance of this polymorphic site remains unknown.