Nonmalabsorptive Mechanisms of Diarrhea in HIV Infection

Nonmalabsorptive Mechanisms of Diarrhea in HIV Infection

More than 50% of AIDS patients suffer from diarrhea, the cause of which is unexplained in 15–40%. In 60–85% a potential cause for diarrhea could be found but the pathogenic relevance often remains unclear. In this paper we review the current knowledge about the nonmalabsorptive mechanisms for diarrh...

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Veröffentlicht in:Pathobiology (Basel) 1998, Vol.66 (3-4), p.165-169
Hauptverfasser: Stockmann, Martin, Fromm, Michael, Riecken, Ernst-Otto, Schulzke, Jörg-Dieter
Format: Artikel
Sprache:eng
Schlagworte:
Diarrhea - complications
Diarrhea - physiopathology
HIV Infections - complications
Humans
Intestinal Absorption
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Zusammenfassung:More than 50% of AIDS patients suffer from diarrhea, the cause of which is unexplained in 15–40%. In 60–85% a potential cause for diarrhea could be found but the pathogenic relevance often remains unclear. In this paper we review the current knowledge about the nonmalabsorptive mechanisms for diarrhea in HIV infection from a pathophysiologic point of view and we show evidence that the diarrhea in advanced HIV infection by HIV per se could be caused by a leak flux mechanism due to an epithelial barrier defect.
ISSN:1015-2008
1423-0291
DOI:10.1159/000028016