Isochroman-6-carboxamides as Highly Selective 5-HT1D Agonists: Potential New Treatment for Migraine without Cardiovascular Side Effects

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1998-06, Vol.41 (13), p.2180-2183
Hauptverfasser:	Ennis, Michael D, Ghazal, Nabil B, Hoffman, Robert L, Smith, Martin W, Schlachter, Siusaidh K, Lawson, Charles F, Im, Wha Bin, Pregenzer, Jeffrey F, Svensson, Kjell A, Lewis, Richard A, Hall, Edward D, Sutter, Dorothy M, Harris, Lorri T, McCall, Robert B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzopyrans - chemistry Benzopyrans - metabolism Benzopyrans - pharmacology Benzopyrans - toxicity Biological and medical sciences Biological Availability Blood Pressure - drug effects Brain - metabolism Capillary Permeability - drug effects Carotid Arteries - drug effects Carotid Arteries - physiology Cats Cell Line Drug Evaluation, Preclinical Dura Mater - blood supply Dura Mater - drug effects Gorilla gorilla Guinea Pigs Hypothermia - metabolism Inflammation - physiopathology Medical sciences Migraine Disorders - drug therapy Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Piperazines - chemistry Piperazines - metabolism Piperazines - pharmacology Piperazines - toxicity Receptor, Serotonin, 5-HT1D Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin Receptor Agonists - chemistry Serotonin Receptor Agonists - metabolism Serotonin Receptor Agonists - pharmacology Serotonin Receptor Agonists - toxicity Serotoninergic system Stereoisomerism Sumatriptan - metabolism Sumatriptan - pharmacology Sumatriptan - toxicity Vascular Resistance - drug effects Vasoconstrictor Agents - chemistry Vasoconstrictor Agents - metabolism Vasoconstrictor Agents - pharmacology Vasoconstrictor Agents - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm980137o