Antidepressant activity of new hetero[2,1]benzothiazepine derivatives

A number of thieno and pyrazolo[2,1]benzothiazepine derivatives as well as several synthetic intermediate compounds were tested for acute toxicity and antidepressant activity in mice. Some of these compounds were effective in the tetrabenazine and Porsolt tests.

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Bibliographische Detailangaben
Veröffentlicht in:	Pharmazie 1998-02, Vol.53 (2), p.130-134
Hauptverfasser:	VEGA, S, DIAZ, J. A, DARIAS, V, SANCHEZ MATEO, C. C, ALBERTOS, L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - pharmacology Animals Antidepressive Agents - chemical synthesis Antidepressive Agents - pharmacology Biological and medical sciences Body Temperature - drug effects Female Hypnotics and Sedatives - pharmacology Male Medical sciences Mice Motor Activity - drug effects Neuropharmacology Pentobarbital - pharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sleep - drug effects Structure-Activity Relationship Swimming Tetrabenazine - pharmacology Thiazepines - chemical synthesis Thiazepines - pharmacology Time Factors
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Beschreibung
Zusammenfassung:	A number of thieno and pyrazolo[2,1]benzothiazepine derivatives as well as several synthetic intermediate compounds were tested for acute toxicity and antidepressant activity in mice. Some of these compounds were effective in the tetrabenazine and Porsolt tests.
ISSN:	0031-7144