Depressed ventilatory response to hypoxia in hypothermic newborn piglets: role of glutamate

1 Division of Neonatology, Department of Pediatrics, and 2 Division of Neuropathology, Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101 To evaluate whether changes in extracellular glutamate (Glu) levels in the central nervous system could explain the depressed...

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Veröffentlicht in:	Journal of applied physiology (1985) 1998-03, Vol.84 (3), p.830-836
Hauptverfasser:	McCormick, Annette, Suguihara, Cleide, Huang, Jian, Devia, Carlos, Hehre, Dorothy, Bruce, Jocelyn H, Bancalari, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium Animals Animals, Newborn - physiology Biological and medical sciences Blood Gas Analysis Brain Stem - physiology Cardiorespiratory control. Arterial mecano- and chemoreceptor Fundamental and applied biological sciences. Psychology Glutamic Acid - physiology Hemodynamics - physiology Hypothermia - physiopathology Hypoxia - physiopathology Microdialysis Oxygen Consumption - physiology Phrenic Nerve - physiology Respiratory Mechanics - physiology Software Swine Vertebrates: respiratory system
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Beschreibung
Zusammenfassung:	1 Division of Neonatology, Department of Pediatrics, and 2 Division of Neuropathology, Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101 To evaluate whether changes in extracellular glutamate (Glu) levels in the central nervous system could explain the depressed hypoxic ventilatory response in hypothermic neonates, 12 anesthetized, paralyzed, and mechanically ventilated piglets
ISSN:	8750-7587 1522-1601
DOI:	10.1152/jappl.1998.84.3.830