Azoxymethane-Induced Liver Hemangiosarcomas in Inbred Strain-2 Guinea Pigs

Intrarectal administration of 0.5 ml of a 0.2% solution of azoxymethane twice weekly for 33 weeks to female inbred strain-2 guinea pigs specifically induced multiple liver hemangiosarcomas in 15 of 16 animals 32–54 weeks after the first treatment. No neoplasms and preneoplastic changes were found in...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1976-03, Vol.56 (3), p.653-654
Hauptverfasser:	Narisawa, Tomio, Wong, Ching-Quo, Weisburger, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azo Compounds - toxicity Azoxymethane - toxicity Guinea Pigs Hemangiosarcoma - chemically induced Injections Liver Neoplasms - chemically induced Neoplasms, Experimental - chemically induced Rectum
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Beschreibung
Zusammenfassung:	Intrarectal administration of 0.5 ml of a 0.2% solution of azoxymethane twice weekly for 33 weeks to female inbred strain-2 guinea pigs specifically induced multiple liver hemangiosarcomas in 15 of 16 animals 32–54 weeks after the first treatment. No neoplasms and preneoplastic changes were found in the large intestine.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/56.3.653