Zanhasaponins A and B, Antiphospholipase A2 Saponins from an Antiinflammatory Extract of Zanha africana Root Bark

A MeOH extract from Z. africana was examined for topical antiinflammatory activity and proved to be active against arachidonic acid (AA) acute edema, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced chronic inflammation, and oxazolone delayed-type hypersensitivity in mice. The extract also showed...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-11, Vol.60 (11), p.1158-1160
Hauptverfasser:	Cuéllar, M. Jesús, Giner, Rosa M, Recio, M. Carmen, Just, M. José, Máñez, Salvador, Cerdá, M, Hostettmann, Kurt, Ríos, José-Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology ANTIINFLAMMATOIRE ANTIINFLAMMATORY AGENTS ANTINFLAMATORIOS AZUCARES ALCOHOLES BARK Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE CORTEZA Dermatitis, Contact - drug therapy Dermatitis, Contact - pathology DRUG PLANTS ECORCE EDEMA Edema - chemically induced Edema - drug therapy Edema - pathology ENZYME INHIBITORS Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology ESPECTROMETRIA ESTERASAS ESTERASE ESTERASES ESTRUCTURA QUIMICA Female General pharmacology HYPERSENSITIVITY INFLAMACION INFLAMMATION INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME MALAWI Medical sciences Mice OEDEMA OEDEME Oxazolone Peroxidase - antagonists & inhibitors Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phospholipases A - antagonists & inhibitors Phospholipases A2 PINITOL PLANTAS MEDICINALES PLANTE MEDICINALE RACINE RAICES REACCIONES ALERGICAS REACTION ALLERGIQUE ROOTS SAPINDACEAE SAPONINAS SAPONINE SAPONINS Saponins - isolation & purification Saponins - pharmacology Skin - pathology SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE SUCRE ALCOOL SUGAR ALCOHOLS Tetradecanoylphorbol Acetate Triterpenes - isolation & purification Triterpenes - pharmacology TRITERPENOIDE TRITERPENOIDOS TRITERPENOIDS
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Zusammenfassung:	A MeOH extract from Z. africana was examined for topical antiinflammatory activity and proved to be active against arachidonic acid (AA) acute edema, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced chronic inflammation, and oxazolone delayed-type hypersensitivity in mice. The extract also showed significant inhibitory activity of Naja naja phospholipase A2 when a polarographic method was used. Two oleanane-type triterpene saponins, zanhasaponins A (1) and B (2), and the cyclitol pinitol (4), isolated from the extract, were active as inhibitors of PLA2. A further saponin, zanhasaponin C (3) was inactive in this assay.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970221r