Low-Density Lipoprotein Ability to Generate Lipoperoxides in Healthy Subjects: Variations According to Age

Oxidized low-density lipoproteins (LDLs) are recognized to be involved in atherosclerosis development. Since the plasma oxidized LDL assay is inadequate because of the short half-lives of LDLs, measurement of the in vitro ability of LDLs to generate lipoperoxides (LDL-GLs) has been preferred. The pr...

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Veröffentlicht in:	Annals of nutrition and metabolism 1997-01, Vol.41 (3), p.160-165
Hauptverfasser:	Tronel, H., Antebi, H., Felden, F., Guerci, B., Fremont, S., Drouin, P., Nicolas, J.P., Alcindor, L.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aging - blood Biological and medical sciences Child Child, Preschool Cholesterol, LDL - blood Female Fundamental and applied biological sciences. Psychology Humans Lipid Peroxides - blood Lipids - blood Lipids. Glycolipids Lipoproteins, LDL - blood Male Malondialdehyde - blood Metabolisms and neurohumoral controls Middle Aged Original Paper Phospholipids - blood Thiobarbituric Acid Reactive Substances - metabolism Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Oxidized low-density lipoproteins (LDLs) are recognized to be involved in atherosclerosis development. Since the plasma oxidized LDL assay is inadequate because of the short half-lives of LDLs, measurement of the in vitro ability of LDLs to generate lipoperoxides (LDL-GLs) has been preferred. The present study displays a profile of LDL-GLs in a group of 175 healthy subjects, using a method to measure thiobarbituric acid-reactive substances. We have observed an increased LDL-GL level according to age.
ISSN:	0250-6807 1421-9697
DOI:	10.1159/000177991