(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen
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| Veröffentlicht in: | Journal of medicinal chemistry 1997-07, Vol.40 (14), p.2117-2122 |
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| container_end_page | 2122 |
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| container_issue | 14 |
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| container_title | Journal of medicinal chemistry |
| container_volume | 40 |
| creator | Gauthier, Sylvain Caron, Brigitte Cloutier, Julie Dory, Yves L Favre, Alexandre Larouche, Denis Mailhot, Josée Ouellet, Carl Schwerdtfeger, Annette Leblanc, Gilles Martel, Céline Simard, Jacques Mérand, Yves Bélanger, Alain Labrie, Claude Labrie, Fernand |
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| doi_str_mv | 10.1021/jm970095o |
| format | Article |
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Drug treatments ; Piperidines - chemistry ; Propionates - chemical synthesis ; Propionates - chemistry ; Propionates - pharmacology ; Raloxifene Hydrochloride ; Receptors, Estrogen - metabolism ; Stereoisomerism ; Structure-Activity Relationship ; Uterus - drug effects ; Uterus - metabolism</subject><ispartof>Journal of medicinal chemistry, 1997-07, Vol.40 (14), p.2117-2122</ispartof><rights>Copyright © 1997 American Chemical Society</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm970095o$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm970095o$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2743272$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9216828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gauthier, Sylvain</creatorcontrib><creatorcontrib>Caron, Brigitte</creatorcontrib><creatorcontrib>Cloutier, Julie</creatorcontrib><creatorcontrib>Dory, Yves L</creatorcontrib><creatorcontrib>Favre, Alexandre</creatorcontrib><creatorcontrib>Larouche, Denis</creatorcontrib><creatorcontrib>Mailhot, Josée</creatorcontrib><creatorcontrib>Ouellet, Carl</creatorcontrib><creatorcontrib>Schwerdtfeger, Annette</creatorcontrib><creatorcontrib>Leblanc, Gilles</creatorcontrib><creatorcontrib>Martel, Céline</creatorcontrib><creatorcontrib>Simard, Jacques</creatorcontrib><creatorcontrib>Mérand, Yves</creatorcontrib><creatorcontrib>Bélanger, Alain</creatorcontrib><creatorcontrib>Labrie, Claude</creatorcontrib><creatorcontrib>Labrie, Fernand</creatorcontrib><title>(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Benzopyrans - chemical synthesis</subject><subject>Benzopyrans - chemistry</subject><subject>Benzopyrans - pharmacology</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cytosol - metabolism</subject><subject>Diethylstilbestrol - metabolism</subject><subject>Estradiol - metabolism</subject><subject>Estrogen Antagonists - chemical synthesis</subject><subject>Estrogen Antagonists - chemistry</subject><subject>Estrogen Antagonists - pharmacology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>Ovariectomy</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - chemistry</subject><subject>Propionates - chemical synthesis</subject><subject>Propionates - chemistry</subject><subject>Propionates - pharmacology</subject><subject>Raloxifene Hydrochloride</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>Uterus - drug effects</subject><subject>Uterus - metabolism</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNklGL00AQgIMoZz198AcI-6DQYkd3ZzfZrG_lPK3Q8w564sNxhE2yuW4vzS5JThqffPVvij_ELS3Fp2Hm-5hhhomil4y-YxTZ-_VGSUpV7B5FIxYjBZFS8TgaUYoImCB_Gj3rujWllDPkJ9GJQpakmI6iv-PlBMZvJyDgRsIYpwgf7cb0q6EGBm7rfOuAeLcddsoBINwEHWHMwFtvWlvaZqgnQAIO5q1fmZDfAs5Dj9w0P50fWt0Ah12V7DH5f1aY4nXjdG_I-PwCUkonH_78-k1mZG7vVvVArlxvmn5Klt4UtrLFlOimJJetrgOcFb39YchX13S9aZ0tdU1mTW9N17fuzjTPoyeVrjvz4hBPo2-fzq_P5rC4_PzlbLYAzRPVgyzTnCnFUiVUnlAlpBGoMK-UKTRVVFCUlWB5ztKYpXlVchGXOZYmj5NAOT-NXu37-od8Y8rMt3aj2yE7XDvw1weuu0LXVbhJYbujhlJwlBg02Gs2rLM9Yt3eZ4nkMs6ur5bZQl58n8cyzUTw3-x9XXTZ2j20TVgyYzTb_UZ2_A3-D82qpbc</recordid><startdate>19970704</startdate><enddate>19970704</enddate><creator>Gauthier, Sylvain</creator><creator>Caron, Brigitte</creator><creator>Cloutier, Julie</creator><creator>Dory, Yves L</creator><creator>Favre, Alexandre</creator><creator>Larouche, Denis</creator><creator>Mailhot, Josée</creator><creator>Ouellet, Carl</creator><creator>Schwerdtfeger, Annette</creator><creator>Leblanc, Gilles</creator><creator>Martel, Céline</creator><creator>Simard, Jacques</creator><creator>Mérand, Yves</creator><creator>Bélanger, Alain</creator><creator>Labrie, Claude</creator><creator>Labrie, Fernand</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19970704</creationdate><title>(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen</title><author>Gauthier, Sylvain ; Caron, Brigitte ; Cloutier, Julie ; Dory, Yves L ; Favre, Alexandre ; Larouche, Denis ; Mailhot, Josée ; Ouellet, Carl ; Schwerdtfeger, Annette ; Leblanc, Gilles ; Martel, Céline ; Simard, Jacques ; Mérand, Yves ; Bélanger, Alain ; Labrie, Claude ; Labrie, Fernand</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a369t-7d8b19918949b60947e4292bf9eca0904027f41bb18518bfd345db2deb5690433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Benzopyrans - chemical synthesis</topic><topic>Benzopyrans - chemistry</topic><topic>Benzopyrans - pharmacology</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cytosol - metabolism</topic><topic>Diethylstilbestrol - metabolism</topic><topic>Estradiol - metabolism</topic><topic>Estrogen Antagonists - chemical synthesis</topic><topic>Estrogen Antagonists - chemistry</topic><topic>Estrogen Antagonists - pharmacology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>Ovariectomy</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - chemistry</topic><topic>Propionates - chemical synthesis</topic><topic>Propionates - chemistry</topic><topic>Propionates - pharmacology</topic><topic>Raloxifene Hydrochloride</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Stereoisomerism</topic><topic>Structure-Activity Relationship</topic><topic>Uterus - drug effects</topic><topic>Uterus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gauthier, Sylvain</creatorcontrib><creatorcontrib>Caron, Brigitte</creatorcontrib><creatorcontrib>Cloutier, Julie</creatorcontrib><creatorcontrib>Dory, Yves L</creatorcontrib><creatorcontrib>Favre, Alexandre</creatorcontrib><creatorcontrib>Larouche, Denis</creatorcontrib><creatorcontrib>Mailhot, Josée</creatorcontrib><creatorcontrib>Ouellet, Carl</creatorcontrib><creatorcontrib>Schwerdtfeger, Annette</creatorcontrib><creatorcontrib>Leblanc, Gilles</creatorcontrib><creatorcontrib>Martel, Céline</creatorcontrib><creatorcontrib>Simard, Jacques</creatorcontrib><creatorcontrib>Mérand, Yves</creatorcontrib><creatorcontrib>Bélanger, Alain</creatorcontrib><creatorcontrib>Labrie, Claude</creatorcontrib><creatorcontrib>Labrie, Fernand</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gauthier, Sylvain</au><au>Caron, Brigitte</au><au>Cloutier, Julie</au><au>Dory, Yves L</au><au>Favre, Alexandre</au><au>Larouche, Denis</au><au>Mailhot, Josée</au><au>Ouellet, Carl</au><au>Schwerdtfeger, Annette</au><au>Leblanc, Gilles</au><au>Martel, Céline</au><au>Simard, Jacques</au><au>Mérand, Yves</au><au>Bélanger, Alain</au><au>Labrie, Claude</au><au>Labrie, Fernand</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1997-07-04</date><risdate>1997</risdate><volume>40</volume><issue>14</issue><spage>2117</spage><epage>2122</epage><pages>2117-2122</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><coden>JMCMAR</coden><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>9216828</pmid><doi>10.1021/jm970095o</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1997-07, Vol.40 (14), p.2117-2122 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_pubmed_primary_9216828 |
| source | ACS Publications; MEDLINE |
| subjects | Administration, Oral Animals Antineoplastic agents Benzopyrans - chemical synthesis Benzopyrans - chemistry Benzopyrans - pharmacology Binding, Competitive Biological and medical sciences Breast Neoplasms - metabolism Cytosol - metabolism Diethylstilbestrol - metabolism Estradiol - metabolism Estrogen Antagonists - chemical synthesis Estrogen Antagonists - chemistry Estrogen Antagonists - pharmacology Female General aspects Humans Medical sciences Mice Molecular Structure Ovariectomy Pharmacology. Drug treatments Piperidines - chemistry Propionates - chemical synthesis Propionates - chemistry Propionates - pharmacology Raloxifene Hydrochloride Receptors, Estrogen - metabolism Stereoisomerism Structure-Activity Relationship Uterus - drug effects Uterus - metabolism |
| title | (S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen |
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