(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen

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Veröffentlicht in:	Journal of medicinal chemistry 1997-07, Vol.40 (14), p.2117-2122
Hauptverfasser:	Gauthier, Sylvain, Caron, Brigitte, Cloutier, Julie, Dory, Yves L, Favre, Alexandre, Larouche, Denis, Mailhot, Josée, Ouellet, Carl, Schwerdtfeger, Annette, Leblanc, Gilles, Martel, Céline, Simard, Jacques, Mérand, Yves, Bélanger, Alain, Labrie, Claude, Labrie, Fernand
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic agents Benzopyrans - chemical synthesis Benzopyrans - chemistry Benzopyrans - pharmacology Binding, Competitive Biological and medical sciences Breast Neoplasms - metabolism Cytosol - metabolism Diethylstilbestrol - metabolism Estradiol - metabolism Estrogen Antagonists - chemical synthesis Estrogen Antagonists - chemistry Estrogen Antagonists - pharmacology Female General aspects Humans Medical sciences Mice Molecular Structure Ovariectomy Pharmacology. Drug treatments Piperidines - chemistry Propionates - chemical synthesis Propionates - chemistry Propionates - pharmacology Raloxifene Hydrochloride Receptors, Estrogen - metabolism Stereoisomerism Structure-Activity Relationship Uterus - drug effects Uterus - metabolism
Online-Zugang:	Volltext
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