Urinary leukotriene E4 and 11‐dehydrothromboxane B2 in patients with aspirin‐sensitive asthma
The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspi...
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| Veröffentlicht in: | Allergy (Copenhagen) 1997-04, Vol.52 (4), p.470-473 |
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| container_title | Allergy (Copenhagen) |
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| creator | Oosaki, R. Mizushima, Y. Mita, H. Shida, T. Akiyama, K. Kobayashi, M. |
| description | The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history of aspirin‐sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg·cr, P |
| doi_str_mv | 10.1111/j.1398-9995.1997.tb01032.x |
| format | Article |
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Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history of aspirin‐sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg·cr, P<0.001), but there was no significant difference in urinary 11DTXB2 between the two groups (891±77 vs 657±90 pg/mg·cr). A high value of LTE4 was not associated with type of asthma, severity of disease, oral prednisolone treatment, sex, or age. A higher value of 11DTXB2 was observed in the atopic type than the nonatopic type in ASA (1086±111 vs 697±147 pg/mg·cr, P<0.05). No correlation was observed between urinary LTE4 and 11DTXB2 in either ASA or NASA. In conclusion, LTs may play an important role in the pathogenesis of ASA, and TXA2 in the pathogenesis of the atopic type in ASA.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.1997.tb01032.x</identifier><identifier>PMID: 9188934</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>11‐dehydrothromboxane B2 ; Aspirin - adverse effects ; aspirin‐sensitive asthma ; Asthma - etiology ; Asthma - urine ; Biological and medical sciences ; Case-Control Studies ; Drug Hypersensitivity - complications ; Drug Hypersensitivity - immunology ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; leukotriene E4 ; Leukotriene E4 - immunology ; Leukotriene E4 - urine ; Male ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Severity of Illness Index ; Thromboxane B2 - analogs & derivatives ; Thromboxane B2 - immunology ; Thromboxane B2 - urine</subject><ispartof>Allergy (Copenhagen), 1997-04, Vol.52 (4), p.470-473</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.1997.tb01032.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.1997.tb01032.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,1433,23929,23930,25139,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2664128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9188934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oosaki, R.</creatorcontrib><creatorcontrib>Mizushima, Y.</creatorcontrib><creatorcontrib>Mita, H.</creatorcontrib><creatorcontrib>Shida, T.</creatorcontrib><creatorcontrib>Akiyama, K.</creatorcontrib><creatorcontrib>Kobayashi, M.</creatorcontrib><title>Urinary leukotriene E4 and 11‐dehydrothromboxane B2 in patients with aspirin‐sensitive asthma</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history of aspirin‐sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg·cr, P<0.001), but there was no significant difference in urinary 11DTXB2 between the two groups (891±77 vs 657±90 pg/mg·cr). A high value of LTE4 was not associated with type of asthma, severity of disease, oral prednisolone treatment, sex, or age. A higher value of 11DTXB2 was observed in the atopic type than the nonatopic type in ASA (1086±111 vs 697±147 pg/mg·cr, P<0.05). No correlation was observed between urinary LTE4 and 11DTXB2 in either ASA or NASA. In conclusion, LTs may play an important role in the pathogenesis of ASA, and TXA2 in the pathogenesis of the atopic type in ASA.</description><subject>11‐dehydrothromboxane B2</subject><subject>Aspirin - adverse effects</subject><subject>aspirin‐sensitive asthma</subject><subject>Asthma - etiology</subject><subject>Asthma - urine</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Drug Hypersensitivity - complications</subject><subject>Drug Hypersensitivity - immunology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>leukotriene E4</subject><subject>Leukotriene E4 - immunology</subject><subject>Leukotriene E4 - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Severity of Illness Index</subject><subject>Thromboxane B2 - analogs & derivatives</subject><subject>Thromboxane B2 - immunology</subject><subject>Thromboxane B2 - urine</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKAzEUhoMotVYfQQjidsZcZ5KNUEu9wIAbuw6ZToZJnRuTVNudj-Az-iRmaGk2B87353DOB8AdRjEO72ETYypFJKXkMZYyjX2OMKIk3p2B6Qmdg2no8ohxKi7BlXMbhFBKJJqAicRCSMqmQK8G2-phD2uz_ez8YE1r4JJB3RYQ47-f38JU-2LofDV0Td7tdMBPBNoW9tqHsHfw2_oKatfbMCl8cKZ11tsvE3q-avQ1uCh17czNsc7A6nn5sXiNsveXt8U8i3qCOIoSQXRe6hyLUGgiOS1zIjVLWFiZFEUiDF5jzgjjEjEpjTCc5ynhKcFpqQs6A7eHuf02b0yh-sE24TB1PDXw-yPXbq3rctDt2rpTjCQJw0SE2OMh9m1rsz9hjNSoXm3U6FeNftWoXh3Vq52aZxlLEf0HFBt6Rg</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>Oosaki, R.</creator><creator>Mizushima, Y.</creator><creator>Mita, H.</creator><creator>Shida, T.</creator><creator>Akiyama, K.</creator><creator>Kobayashi, M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199704</creationdate><title>Urinary leukotriene E4 and 11‐dehydrothromboxane B2 in patients with aspirin‐sensitive asthma</title><author>Oosaki, R. ; Mizushima, Y. ; Mita, H. ; Shida, T. ; Akiyama, K. ; Kobayashi, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2050-682abfab18abf36953fb29a4647292dd68e1c15424590499e8e55b7257217fad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>11‐dehydrothromboxane B2</topic><topic>Aspirin - adverse effects</topic><topic>aspirin‐sensitive asthma</topic><topic>Asthma - etiology</topic><topic>Asthma - urine</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Drug Hypersensitivity - complications</topic><topic>Drug Hypersensitivity - immunology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>leukotriene E4</topic><topic>Leukotriene E4 - immunology</topic><topic>Leukotriene E4 - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Severity of Illness Index</topic><topic>Thromboxane B2 - analogs & derivatives</topic><topic>Thromboxane B2 - immunology</topic><topic>Thromboxane B2 - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oosaki, R.</creatorcontrib><creatorcontrib>Mizushima, Y.</creatorcontrib><creatorcontrib>Mita, H.</creatorcontrib><creatorcontrib>Shida, T.</creatorcontrib><creatorcontrib>Akiyama, K.</creatorcontrib><creatorcontrib>Kobayashi, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oosaki, R.</au><au>Mizushima, Y.</au><au>Mita, H.</au><au>Shida, T.</au><au>Akiyama, K.</au><au>Kobayashi, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary leukotriene E4 and 11‐dehydrothromboxane B2 in patients with aspirin‐sensitive asthma</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>1997-04</date><risdate>1997</risdate><volume>52</volume><issue>4</issue><spage>470</spage><epage>473</epage><pages>470-473</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history of aspirin‐sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg·cr, P<0.001), but there was no significant difference in urinary 11DTXB2 between the two groups (891±77 vs 657±90 pg/mg·cr). A high value of LTE4 was not associated with type of asthma, severity of disease, oral prednisolone treatment, sex, or age. A higher value of 11DTXB2 was observed in the atopic type than the nonatopic type in ASA (1086±111 vs 697±147 pg/mg·cr, P<0.05). No correlation was observed between urinary LTE4 and 11DTXB2 in either ASA or NASA. In conclusion, LTs may play an important role in the pathogenesis of ASA, and TXA2 in the pathogenesis of the atopic type in ASA.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9188934</pmid><doi>10.1111/j.1398-9995.1997.tb01032.x</doi><tpages>4</tpages></addata></record> |
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| subjects | 11‐dehydrothromboxane B2 Aspirin - adverse effects aspirin‐sensitive asthma Asthma - etiology Asthma - urine Biological and medical sciences Case-Control Studies Drug Hypersensitivity - complications Drug Hypersensitivity - immunology Drug toxicity and drugs side effects treatment Female Humans leukotriene E4 Leukotriene E4 - immunology Leukotriene E4 - urine Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Severity of Illness Index Thromboxane B2 - analogs & derivatives Thromboxane B2 - immunology Thromboxane B2 - urine |
| title | Urinary leukotriene E4 and 11‐dehydrothromboxane B2 in patients with aspirin‐sensitive asthma |
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