Urinary leukotriene E4 and 11‐dehydrothromboxane B2 in patients with aspirin‐sensitive asthma

The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspi...

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Veröffentlicht in:	Allergy (Copenhagen) 1997-04, Vol.52 (4), p.470-473
Hauptverfasser:	Oosaki, R., Mizushima, Y., Mita, H., Shida, T., Akiyama, K., Kobayashi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	11‐dehydrothromboxane B2 Aspirin - adverse effects aspirin‐sensitive asthma Asthma - etiology Asthma - urine Biological and medical sciences Case-Control Studies Drug Hypersensitivity - complications Drug Hypersensitivity - immunology Drug toxicity and drugs side effects treatment Female Humans leukotriene E4 Leukotriene E4 - immunology Leukotriene E4 - urine Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Severity of Illness Index Thromboxane B2 - analogs & derivatives Thromboxane B2 - immunology Thromboxane B2 - urine
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Zusammenfassung:	The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11‐dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history of aspirin‐sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg·cr, P
ISSN:	0105-4538 1398-9995
DOI:	10.1111/j.1398-9995.1997.tb01032.x