Physiological melatonin inhibition of human breast cancer cell growth in vitro : Evidence for a glutathione-mediated pathway

Melatonin, the chief hormone secreted by the pineal gland, has been previously shown to inhibit human breast cancer cell growth at the physiological concentration of 1 nM in vitro. In this study, using the estrogen receptor (ER)-positive human breast tumor cell line MCF-7, we have shown that 10 micr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-05, Vol.57 (10), p.1909-1914
Hauptverfasser:	BLASK, D. E, WILSON, S. T, ZALATAN, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents, Hormonal - pharmacology Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Buthionine Sulfoximine - pharmacology Cell Division - drug effects Cell Division - physiology Diuretics - pharmacology Ethacrynic Acid - pharmacology Female Glutathione - metabolism Glutathione - pharmacology Glutathione - physiology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Melatonin - pharmacology Melatonin - physiology Receptors, Estrogen - physiology Tamoxifen - pharmacology Tumor Cells, Cultured Tumors
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