Induction of hepatic aryl hydrocarbon hydroxylase in C57BL mice by ionizing radiation

Inbred strains of C57BL mice were exposed to either 100, 500, or 1000 rads of whole-body irradiation. Another group of mice were given injections of 3-methylcholanthrene only, and a control group had no treatment. Forty-eight hr after treatment, the animals were killed and hepatic aryl hydrocarbon h...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1977-10, Vol.37 (10), p.3771
Hauptverfasser:	Prasad, N, Prasad, R, Thornby, J, Bushong, S C, North, L B, Harrell, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Dose-Response Relationship, Radiation Enzyme Induction - drug effects Enzyme Induction - radiation effects Female Liver - drug effects Liver - enzymology Liver - radiation effects Male Methylcholanthrene - pharmacology Mice Mice, Inbred C57BL X-Rays
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Zusammenfassung:	Inbred strains of C57BL mice were exposed to either 100, 500, or 1000 rads of whole-body irradiation. Another group of mice were given injections of 3-methylcholanthrene only, and a control group had no treatment. Forty-eight hr after treatment, the animals were killed and hepatic aryl hydrocarbon hydroxylase (AHH) activity was measured by spectrophotofluorometer. A comparison of hepatic AHH activity in treated and nontreated groups of mice showed that each treated group had a significantly increased AHH induction compared with the control group. Although radiation appeared to have a dose-related effect on AHH induction, the increase with dose level was not statistically significant.
ISSN:	0008-5472