Chemistry of indoles carrying a basic function, Part 3 : Synthesis of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H)-ones with antihypoxic effects

Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7, 9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21-32) with dimethylo...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1996-12, Vol.329 (12), p.541-549
Hauptverfasser:	MOLDVAI, I, GACS-BAITZ, E, BALAZS, M, INCZE, M, SZANTAY, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pressure Animals Biological and medical sciences Brain Edema - chemically induced Brain Edema - etiology Brain Edema - prevention & control Hypoxia - complications Hypoxia - drug therapy Indoles - chemical synthesis Indoles - chemistry Indoles - therapeutic use Magnetic Resonance Spectroscopy Medical sciences Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rats Rats, Inbred SHR Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Spiro Compounds - therapeutic use Triethyltin Compounds
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Zusammenfassung:	Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7, 9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21-32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.
ISSN:	0365-6233 1521-4184