Bone resorption inhibitors from hop extract

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997-01, Vol.61 (1), p.158-159
Hauptverfasser:	Tobe, H. (Hoechst Japan Ltd., Kawagoe, Saitama), Muraki, Y, Kitamura, K, Komiyama, O, Sato, Y, Sugioka, T, Maruyama, H.B, Matsuda, E, Nagai, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Bone Resorption - drug therapy bone resorption inhibitor BONES Cyclohexenes Dose-Response Relationship, Drug EXTRACTOS EXTRACTS EXTRAIT Flavonoids General pharmacology hop extract HUESOS humulone HUMULUS LUPULUS INHIBICION INHIBITION Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Edible - chemistry Propiophenones - chemistry Propiophenones - pharmacology Structure-Activity Relationship Terpenes - chemistry Terpenes - pharmacology xanthohumol
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Zusammenfassung:	We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.61.158