The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes

Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing by cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions...

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Veröffentlicht in:	Infection and Immunity 1996-11, Vol.64 (11), p.4838-4841
Hauptverfasser:	Elzer, P.H. (Louisiana State University Agricultural Center, Baton Rouge.), Phillips, R.W, Robertson, G.T, Roop, R.M. II
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences BRUCELLA ABORTUS Brucella abortus - enzymology Brucella abortus - genetics Brucella abortus - immunology Brucella abortus - pathogenicity Brucellosis - immunology Brucellosis - microbiology Cells, Cultured Fundamental and applied biological sciences. Psychology Heat-Shock Proteins Macrophages - immunology Mice Mice, Inbred BALB C Microbiology Mutation Neutrophils - immunology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Periplasmic Proteins Phagocytes - immunology Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Virulence
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Zusammenfassung:	Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing by cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions of the htrA gene product to the pathogenesis of B. abortus infections
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.64.11.4838-4841.1996