(+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes
A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene...
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| Veröffentlicht in: | Zeitschrift für Naturforschung C. A journal of biosciences 1996-07, Vol.51 (7-8), p.487 |
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| container_title | Zeitschrift für Naturforschung C. A journal of biosciences |
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| creator | Zapf, S Wunder, A Anke, T Klostermeyer, D Steglich, W Shan, R Sterner, O Scheuer, W |
| description | A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3 alpha-hydroxy-T-cadinol, three related sesquiterpenes. |
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The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3 alpha-hydroxy-T-cadinol, three related sesquiterpenes.</abstract><cop>Germany</cop><pmid>8810091</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5075 |
| ispartof | Zeitschrift für Naturforschung C. A journal of biosciences, 1996-07, Vol.51 (7-8), p.487 |
| issn | 0939-5075 |
| language | eng |
| recordid | cdi_pubmed_primary_8810091 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - toxicity Calcium - pharmacology Cell Line Cell Survival - drug effects Dinoprostone - biosynthesis Dinoprostone - blood Fermentation HeLa Cells HL-60 Cells Humans In Vitro Techniques Leukemia L1210 Leukocytes - drug effects Leukocytes - metabolism Leukotriene Antagonists Leukotriene C4 - biosynthesis Leukotriene C4 - blood Leukotrienes - biosynthesis Mice Molecular Conformation Molecular Structure Polyporaceae Rats Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology |
| title | (+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes |
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