(+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes

A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Zeitschrift für Naturforschung C. A journal of biosciences 1996-07, Vol.51 (7-8), p.487
Hauptverfasser:	Zapf, S, Wunder, A, Anke, T, Klostermeyer, D, Steglich, W, Shan, R, Sterner, O, Scheuer, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - toxicity Calcium - pharmacology Cell Line Cell Survival - drug effects Dinoprostone - biosynthesis Dinoprostone - blood Fermentation HeLa Cells HL-60 Cells Humans In Vitro Techniques Leukemia L1210 Leukocytes - drug effects Leukocytes - metabolism Leukotriene Antagonists Leukotriene C4 - biosynthesis Leukotriene C4 - blood Leukotrienes - biosynthesis Mice Molecular Conformation Molecular Structure Polyporaceae Rats Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3 alpha-hydroxy-T-cadinol, three related sesquiterpenes.
ISSN:	0939-5075