Test for carcinogenicity of organic contaminants of United States drinking waters by pulmonary tumor response in strain A mice

The production of lung adenomas in strain A following multiple i.p. injections of selected organic water contaminants was investigated. Of the 16 contaminants tested, only bromoform produced a pulmonary adenoma response that was significantly greater than the pulmonary adenoma response of vehicle-tr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1977-08, Vol.37 (8 Pt 1), p.2717
Hauptverfasser:	Theiss, J C, Stoner, G D, Shimkin, M B, Weisburger, E K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - chemically induced Animals Carcinogens, Environmental Drug Evaluation, Preclinical Hydrocarbons, Brominated - poisoning Lung Neoplasms - chemically induced Male Methylene Chloride - poisoning Mice Mice, Inbred A Neoplasms, Experimental - chemically induced United States Water Pollutants - toxicity Water Pollutants, Chemical - toxicity
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Zusammenfassung:	The production of lung adenomas in strain A following multiple i.p. injections of selected organic water contaminants was investigated. Of the 16 contaminants tested, only bromoform produced a pulmonary adenoma response that was significantly greater than the pulmonary adenoma response of vehicle-treated control mice.
ISSN:	0008-5472