In vitro evaluation of the cytotoxicity of calcium hydroxide-based root canal sealers

In vitro evaluation of the cytotoxicity of calcium hydroxide-based root canal sealers

The cytotoxicity of three calcium hydroxide-containing root canal sealers (Sealapex, CRCS and Apexit) was tested by using L929 and BHK 21/C13 cells. After setting for 24 h, the sealers were covered with cell suspension. Cytotoxicity was determined by a quantitative technique at 24 h, 48 h and 72 h....

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Veröffentlicht in:Endodontics & dental traumatology 1995-10, Vol.11 (5), p.245
Hauptverfasser: Beltes, P, Koulaouzidou, E, Kotoula, V, Kortsaris, A H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Calcium Hydroxide - toxicity
Cells, Cultured
Cricetinae
Evaluation Studies as Topic
Fibroblasts - drug effects
Kidney - cytology
L Cells (Cell Line)
Mice
Root Canal Filling Materials - toxicity
Salicylates - toxicity
Zinc Oxide - toxicity
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Zusammenfassung:The cytotoxicity of three calcium hydroxide-containing root canal sealers (Sealapex, CRCS and Apexit) was tested by using L929 and BHK 21/C13 cells. After setting for 24 h, the sealers were covered with cell suspension. Cytotoxicity was determined by a quantitative technique at 24 h, 48 h and 72 h. All the sealers were found to be cytotoxic. Sealapex showed the highest cytotoxicity, causing a significant decrease in cell density. CRCS was less toxic than Sealapex and more toxic than Apexit. Apexit proved to be the least toxic material.
ISSN:0109-2502