The safety and tolerability of cyclosporine emulsion versus cyclosporine in a randomized, double-blind comparison in primary renal allograft recipients. The Neoral Study Group

A 12-week, randomized, double-blind, multicenter pharmacokinetics study was conducted to compare the clinical safety and tolerability of cyclosporine capsules and oral solution for microemulsion and cyclosporine in 101 primary renal transplant recipients Cyclosporine emulsion has more complete absor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 1996-03, Vol.61 (6), p.968
Hauptverfasser:	Barone, G, Bunke, C M, Choc, Jr, M G, Hricik, D E, Jin, J H, Klein, J B, Marsh, C L, Min, D I, Pescovitz, M D, Pollak, R, Pruett, T L, Stinson, J B, Thompson, J S, Vasquez, E, Waid, T, Wombolt, D G, Wong, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Aged Biological Availability Capsules Cyclosporine - administration & dosage Cyclosporine - adverse effects Cyclosporine - pharmacokinetics Double-Blind Method Emulsions Female Graft Survival - drug effects Humans Kidney Transplantation Male Middle Aged
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A 12-week, randomized, double-blind, multicenter pharmacokinetics study was conducted to compare the clinical safety and tolerability of cyclosporine capsules and oral solution for microemulsion and cyclosporine in 101 primary renal transplant recipients Cyclosporine emulsion has more complete absorption and improved bioavailability compared with cyclosporine, and dosing of both cyclosporine formulations was adjusted to achieve comparable whole-blood trough levels. Mean serum creatinine values were higher in the cyclosporine emulsion group at baseline, 8, and 12 weeks (P
ISSN:	0041-1337