Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma
We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extran...
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| Veröffentlicht in: | Journal of immunotherapy 1995-08, Vol.18 (2), p.124-126 |
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| container_end_page | 126 |
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| container_issue | 2 |
| container_start_page | 124 |
| container_title | Journal of immunotherapy |
| container_volume | 18 |
| creator | MICHEL, M VINCENT, F SIGAL, R DAMAJ, G BENSOUSAN, T. A LECLERCQ, B ESCUDIER, B |
| description | We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy. |
| doi_str_mv | 10.1097/00002371-199508000-00007 |
| format | Article |
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A ; LECLERCQ, B ; ESCUDIER, B</creator><creatorcontrib>MICHEL, M ; VINCENT, F ; SIGAL, R ; DAMAJ, G ; BENSOUSAN, T. A ; LECLERCQ, B ; ESCUDIER, B</creatorcontrib><description>We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.</description><identifier>ISSN: 1067-5582</identifier><identifier>ISSN: 1524-9557</identifier><identifier>ISSN: 1053-8550</identifier><identifier>EISSN: 2331-3676</identifier><identifier>DOI: 10.1097/00002371-199508000-00007</identifier><identifier>PMID: 8574468</identifier><language>eng</language><publisher>New York, NY: Raven Press</publisher><subject>Adult ; Biological and medical sciences ; Brain - blood supply ; Brain - pathology ; Carcinoma, Renal Cell - drug therapy ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Interleukin-2 - adverse effects ; Magnetic Resonance Imaging ; Medical sciences ; Pharmacology. 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A</creatorcontrib><creatorcontrib>LECLERCQ, B</creatorcontrib><creatorcontrib>ESCUDIER, B</creatorcontrib><title>Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma</title><title>Journal of immunotherapy</title><addtitle>J Immunother Emphasis Tumor Immunol</addtitle><description>We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - pathology</subject><subject>Carcinoma, Renal Cell - drug therapy</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-2 - adverse effects</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: nervous system and muscle</subject><subject>Vasculitis - chemically induced</subject><subject>Vasculitis - pathology</subject><issn>1067-5582</issn><issn>1524-9557</issn><issn>1053-8550</issn><issn>2331-3676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEGmPwE5B6QNwC-WjzcUQTMKRJXOBcuZkjCv0YSYu0f0_KxnywZft9neghJOPsjjOr71kKITWn3NqCmdTRaaRPyFxIyalUWp2SOWdK06Iw4pxcxPjJWCEFlzMyM4XOc2XmZLXEgFWAJvuB6MamHuqYgR8wZHWXcoPjV91RkQ0fGGC7y3wfsoBdMjhsUoLg6q5v4ZKceWgiXh3qgrw_Pb4tV3T9-vyyfFhTJzUbaO50hRqEAs9RWC49COkN5N4azjwyZdG6qlJaWuclVhqMBXQbbllVVFYuyO3-7jb03yPGoWzrOH0FOuzHWHJlLSuMTkKzF7rQxxjQl9tQtxB2JWflBLH8h1geIf6NJuv14Y2xanFzNB6opf3NYZ-YQeMDdK6OR5kwNrfpzC-1DXpJ</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>MICHEL, M</creator><creator>VINCENT, F</creator><creator>SIGAL, R</creator><creator>DAMAJ, G</creator><creator>BENSOUSAN, T. A</creator><creator>LECLERCQ, B</creator><creator>ESCUDIER, B</creator><general>Raven Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19950801</creationdate><title>Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma</title><author>MICHEL, M ; VINCENT, F ; SIGAL, R ; DAMAJ, G ; BENSOUSAN, T. 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Drug treatments</topic><topic>Toxicity: nervous system and muscle</topic><topic>Vasculitis - chemically induced</topic><topic>Vasculitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MICHEL, M</creatorcontrib><creatorcontrib>VINCENT, F</creatorcontrib><creatorcontrib>SIGAL, R</creatorcontrib><creatorcontrib>DAMAJ, G</creatorcontrib><creatorcontrib>BENSOUSAN, T. A</creatorcontrib><creatorcontrib>LECLERCQ, B</creatorcontrib><creatorcontrib>ESCUDIER, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MICHEL, M</au><au>VINCENT, F</au><au>SIGAL, R</au><au>DAMAJ, G</au><au>BENSOUSAN, T. A</au><au>LECLERCQ, B</au><au>ESCUDIER, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma</atitle><jtitle>Journal of immunotherapy</jtitle><addtitle>J Immunother Emphasis Tumor Immunol</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>18</volume><issue>2</issue><spage>124</spage><epage>126</epage><pages>124-126</pages><issn>1067-5582</issn><issn>1524-9557</issn><issn>1053-8550</issn><eissn>2331-3676</eissn><abstract>We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.</abstract><cop>New York, NY</cop><pub>Raven Press</pub><pmid>8574468</pmid><doi>10.1097/00002371-199508000-00007</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1067-5582 |
| ispartof | Journal of immunotherapy, 1995-08, Vol.18 (2), p.124-126 |
| issn | 1067-5582 1524-9557 1053-8550 2331-3676 |
| language | eng |
| recordid | cdi_pubmed_primary_8574468 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Brain - blood supply Brain - pathology Carcinoma, Renal Cell - drug therapy Drug toxicity and drugs side effects treatment Female Humans Interleukin-2 - adverse effects Magnetic Resonance Imaging Medical sciences Pharmacology. Drug treatments Toxicity: nervous system and muscle Vasculitis - chemically induced Vasculitis - pathology |
| title | Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma |
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