Cerebral vasculitis after interleukin-2 therapy for renal cell carcinoma

We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extran...

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Veröffentlicht in:	Journal of immunotherapy 1995-08, Vol.18 (2), p.124-126
Hauptverfasser:	MICHEL, M, VINCENT, F, SIGAL, R, DAMAJ, G, BENSOUSAN, T. A, LECLERCQ, B, ESCUDIER, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain - blood supply Brain - pathology Carcinoma, Renal Cell - drug therapy Drug toxicity and drugs side effects treatment Female Humans Interleukin-2 - adverse effects Magnetic Resonance Imaging Medical sciences Pharmacology. Drug treatments Toxicity: nervous system and muscle Vasculitis - chemically induced Vasculitis - pathology
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Beschreibung
Zusammenfassung:	We report one patient with paralysis of the right upper extremity, bilateral cerebellar syndrome, and cognitive changes after treatment with interleukin-2 for metastatic renal cell carcinoma. Focal neurologic disturbances were associated with multiple images of cerebral infarcts but also with extraneurologic signs and autoantibodies. We suggest that this is a case of cerebral vasculitis with an autoimmune mechanism triggered by interleukin-2 therapy.
ISSN:	1067-5582 1524-9557 1053-8550 2331-3676
DOI:	10.1097/00002371-199508000-00007