The bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation
We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infe...
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| Veröffentlicht in: | Journal of Virology 1996-01, Vol.70 (1), p.663-666 |
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| container_end_page | 666 |
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| container_title | Journal of Virology |
| container_volume | 70 |
| creator | Olsen, C.W. (University of Wisconsin-Madison, Madison, WI.) Kehren, J.C Dybdahl-Sissoko, N.R Hinshaw, V.S |
| description | We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein |
| doi_str_mv | 10.1128/jvi.70.1.663-666.1996 |
| format | Article |
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(University of Wisconsin-Madison, Madison, WI.)</creatorcontrib><creatorcontrib>Kehren, J.C</creatorcontrib><creatorcontrib>Dybdahl-Sissoko, N.R</creatorcontrib><creatorcontrib>Hinshaw, V.S</creatorcontrib><title>The bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein</description><subject>AGGLUTININE</subject><subject>AGLUTININAS</subject><subject>Animals</subject><subject>Cell Line</subject><subject>Chick Embryo</subject><subject>CHIEN</subject><subject>CULTIVO DE CELULAS</subject><subject>CULTURE DE CELLULE</subject><subject>Dogs</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>GENE</subject><subject>GENES</subject><subject>Glycosylation</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus</subject><subject>Hemagglutinins, Viral - metabolism</subject><subject>Humans</subject><subject>influenza A virus</subject><subject>INFLUENZAVIRUS AVIAIRE</subject><subject>INHIBICION</subject><subject>INHIBITION</subject><subject>Orthomyxoviridae - growth & development</subject><subject>Orthomyxoviridae - metabolism</subject><subject>PERRO</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-bcl-2</subject><subject>REACCIONES QUIMICAS</subject><subject>REACTION CHIMIQUE</subject><subject>REIN</subject><subject>RINONES</subject><subject>VIRUS DE LA INFLUENZA AVIAR</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVpSLdpv0Ah4FNP8UYjWf8OPZTQtIVADk2gN6GVZVtBlreSvWXz6aOwS2hOPQwz8H5vkOYhdA54DUDk5cPOr0WZ15zTmnO-BqX4G7QCrGTNGDRv0QpjQmpG5e936H3ODxhD0_DmFJ1KRihTeIVu7wZXbWyoSWXC7FKufOzC4uKjqXY-LbnaexfaiypvkzOlm9hWgxtN34dl9tHHqg97O-V9MLOf4gd00pmQ3cdjP0P319_urn7UN7fff159vaktU3KurcKCSde4BoMlWEprOcUbYjkXjhsuKVjVNsxS1SpKOxCYOCklZUBUowQ9Q18Oe7fLZnStdXFOJuht8qNJez0Zr18r0Q-6n3YapJKcFv_noz9NfxaXZz36bF0IJrppyVoIhXE50n9B4EoKAFZAdgBtmnJOrnt5DGD9nJguiWlRZl0SK8X1c2LFd_7vT15cx4iKXh30wffDX5-cNnl8tasgnw5IZyZt-uSzvv-lOAAHSp8AaqemGA</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Olsen, C.W. 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(University of Wisconsin-Madison, Madison, WI.) ; Kehren, J.C ; Dybdahl-Sissoko, N.R ; Hinshaw, V.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-c90758e4e401c2088cc630b2c667e6a6831c9d45c39d933f1702e888351294973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AGGLUTININE</topic><topic>AGLUTININAS</topic><topic>Animals</topic><topic>Cell Line</topic><topic>Chick Embryo</topic><topic>CHIEN</topic><topic>CULTIVO DE CELULAS</topic><topic>CULTURE DE CELLULE</topic><topic>Dogs</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>GENE</topic><topic>GENES</topic><topic>Glycosylation</topic><topic>Hemagglutinin Glycoproteins, Influenza Virus</topic><topic>Hemagglutinins, Viral - metabolism</topic><topic>Humans</topic><topic>influenza A virus</topic><topic>INFLUENZAVIRUS AVIAIRE</topic><topic>INHIBICION</topic><topic>INHIBITION</topic><topic>Orthomyxoviridae - growth & development</topic><topic>Orthomyxoviridae - metabolism</topic><topic>PERRO</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-bcl-2</topic><topic>REACCIONES QUIMICAS</topic><topic>REACTION CHIMIQUE</topic><topic>REIN</topic><topic>RINONES</topic><topic>VIRUS DE LA INFLUENZA AVIAR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olsen, C.W. (University of Wisconsin-Madison, Madison, WI.)</creatorcontrib><creatorcontrib>Kehren, J.C</creatorcontrib><creatorcontrib>Dybdahl-Sissoko, N.R</creatorcontrib><creatorcontrib>Hinshaw, V.S</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olsen, C.W. (University of Wisconsin-Madison, Madison, WI.)</au><au>Kehren, J.C</au><au>Dybdahl-Sissoko, N.R</au><au>Hinshaw, V.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation</atitle><jtitle>Journal of Virology</jtitle><addtitle>J Virol</addtitle><date>1996-01</date><risdate>1996</risdate><volume>70</volume><issue>1</issue><spage>663</spage><epage>666</epage><pages>663-666</pages><issn>0022-538X</issn><eissn>1098-5514</eissn><abstract>We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>8523590</pmid><doi>10.1128/jvi.70.1.663-666.1996</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Virology, 1996-01, Vol.70 (1), p.663-666 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | AGGLUTININE AGLUTININAS Animals Cell Line Chick Embryo CHIEN CULTIVO DE CELULAS CULTURE DE CELLULE Dogs EXPRESION GENICA EXPRESSION DES GENES GENE GENES Glycosylation Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins, Viral - metabolism Humans influenza A virus INFLUENZAVIRUS AVIAIRE INHIBICION INHIBITION Orthomyxoviridae - growth & development Orthomyxoviridae - metabolism PERRO Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 REACCIONES QUIMICAS REACTION CHIMIQUE REIN RINONES VIRUS DE LA INFLUENZA AVIAR |
| title | The bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation |
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