The bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation

We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infe...

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Veröffentlicht in:	Journal of Virology 1996-01, Vol.70 (1), p.663-666
Hauptverfasser:	Olsen, C.W. (University of Wisconsin-Madison, Madison, WI.), Kehren, J.C, Dybdahl-Sissoko, N.R, Hinshaw, V.S
Format:	Artikel
Sprache:	eng
Schlagworte:	AGGLUTININE AGLUTININAS Animals Cell Line Chick Embryo CHIEN CULTIVO DE CELULAS CULTURE DE CELLULE Dogs EXPRESION GENICA EXPRESSION DES GENES GENE GENES Glycosylation Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins, Viral - metabolism Humans influenza A virus INFLUENZAVIRUS AVIAIRE INHIBICION INHIBITION Orthomyxoviridae - growth & development Orthomyxoviridae - metabolism PERRO Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 REACCIONES QUIMICAS REACTION CHIMIQUE REIN RINONES VIRUS DE LA INFLUENZA AVIAR
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Zusammenfassung:	We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein
ISSN:	0022-538X 1098-5514
DOI:	10.1128/jvi.70.1.663-666.1996