Erythromycin-antacid interaction

Erythromycin-antacid interaction

The in vitro release of erythromycin stearate in the presence of aluminium hydroxide, aluminium trisilicate, magnesium oxide, magnesium trisilicate, sodium hydrogen carbonate and a combination of aluminium hydroxide gel, magnesium hydroxide and dimethyl polysiloxane has been studied by the USP XX di...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmazie 1993-08, Vol.48 (8), p.599-602
Hauptverfasser: SAEED ARAYNE, M, NAJMA SULTANA
Format: Artikel
Sprache:eng
Schlagworte:
Antacids - chemistry
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Chemistry, Pharmaceutical
Drug Interactions
Erythromycin - chemistry
Erythromycin - pharmacokinetics
Medical sciences
Pharmacology. Drug treatments
Solubility
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The in vitro release of erythromycin stearate in the presence of aluminium hydroxide, aluminium trisilicate, magnesium oxide, magnesium trisilicate, sodium hydrogen carbonate and a combination of aluminium hydroxide gel, magnesium hydroxide and dimethyl polysiloxane has been studied by the USP XX dissolution method. The dissolution of erythromycin was found to be markedly retarded in the presence of all the antacids studied except sodium hydrogen carbonate. An attempt was made to elucidate the mechanism of this effect.
ISSN:0031-7144