Simple methods of chloroquine determination in urine and their adaptation in the field

Field malaria studies require often the on site detection of chloroquine in urine for monitoring chemoprophylaxis and treatment compliance, investigating drug-use patterns and screening prospective subjects for in vitro and in vivo chemosensitivity tests. The field adapted methods are described, ana...

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Veröffentlicht in:	Médecine tropicale 1993-04, Vol.53 (2), p.241
Hauptverfasser:	Chaulet, J F, Robet, Y, Prevosto, J M, Grelaud, G, Renard, C, Bellemin-Magninot, P, Lemontey, Y
Format:	Magazinearticle
Sprache:	fre
Schlagworte:	Chloroquine - metabolism Chloroquine - therapeutic use Chloroquine - urine Chromatography - methods Clinical Protocols Colorimetry - methods Drug Interactions Drug Monitoring - methods Drug Resistance Evaluation Studies as Topic Hematuria - complications Humans Hydrogen-Ion Concentration Immunoenzyme Techniques Malaria, Falciparum - complications Malaria, Falciparum - drug therapy Malaria, Falciparum - psychology Malaria, Falciparum - urine Nephelometry and Turbidimetry - methods Patient Compliance Reproducibility of Results Sensitivity and Specificity
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Zusammenfassung:	Field malaria studies require often the on site detection of chloroquine in urine for monitoring chemoprophylaxis and treatment compliance, investigating drug-use patterns and screening prospective subjects for in vitro and in vivo chemosensitivity tests. The field adapted methods are described, analytical characteristics are compared and different approaches to field adapted assay of chloroquine are discussed.
ISSN:	0025-682X