STUDIES ON SYNERGISTIC EFFECT OF SULBENICILLIN AND DIBEKACIN AGAINST GRAM-NEGATIVE BACILLI

In vitro synergism of sulbenicillin and dibekacin was investigated with 19 strains of E. coli, 20strains of Enterobacter and 20 strains of Pseudomonas aeruginosa on agar plates. As the results, sulbenicillin and dibekacin were found to be synergistically bacteriostatic against all these organisms, though the synergistic effects were somewhat less potent against E. coli. The concentrations of dibekacin required for assuming a clear synergism were 0.78-1.56μg/ml.