Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH

Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on re...

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Veröffentlicht in:	Brain research 1994-05, Vol.646 (2), p.319-323
Hauptverfasser:	Keren, O., Garty, M., Sarne, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catecholamine Cell Line Cell physiology Dextrorphan - pharmacology Drug Interactions Enkephalin, Ala-MePhe-Gly Enkephalin, D-Penicillamine (2,5) Enkephalins - pharmacology Fundamental and applied biological sciences. Psychology Humans Kinetics Levorphanol - pharmacology Molecular and cellular biology Morphine - pharmacology Naloxone - pharmacology Narcotics - pharmacology Neuroblastoma - metabolism Neurotransmission Neurotransmitter release Norepinephrine Norepinephrine - metabolism Opioid receptor Receptors, Opioid - drug effects Receptors, Opioid - physiology SK-N-SH cell Tritium Tumor Cells, Cultured
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Zusammenfassung:	Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(94)90098-1