Erythrocyte transketolases and Alzheimer disease

Erythrocyte transketolases and Alzheimer disease

Abnormalities of thiamin metabolism have been reported in senile dementia of Alzheimer's type (SDAT). Transketolases (TK) were studied in 21 patients with SDAT, 24 age-matched controls and 12 chronic alcoholics. Erythrocytes were assessed for their TK activity coefficient (TK-AC, normal value 8...

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Veröffentlicht in:La revue de medecine interne 1994-05, Vol.15 (6), p.387
Hauptverfasser: Eisinger, J, Arroyo, P, Braquet, M, Arroyo, H, Ayavou, T
Format: Artikel
Sprache:fre
Schlagworte:
Aged
Aged, 80 and over
Alcoholism - blood
Alcoholism - enzymology
Alzheimer Disease - enzymology
Enzyme Activation
Erythrocytes - enzymology
Female
Humans
Male
Thiamine Pyrophosphate - metabolism
Transketolase - metabolism
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Zusammenfassung:Abnormalities of thiamin metabolism have been reported in senile dementia of Alzheimer's type (SDAT). Transketolases (TK) were studied in 21 patients with SDAT, 24 age-matched controls and 12 chronic alcoholics. Erythrocytes were assessed for their TK activity coefficient (TK-AC, normal value 8.4 +/- 12.6%) and affinity for thaimin pyrophosphate (Km TPP, normal value 17.8 +/- 8.3 mumol). Comparison between study groups and controls demonstrated increased TK-AC in SDAT (16.6 +/- 15.7%, P < 0.05) and chronic alcoholism (43.4 +/- 40.6%, P < 0.05), and increased Km TPP (38.3 +/- 25.2 mumol, P < 0.01) in SDAT only. These findings suggest structural abnormalities of TK rather than vitamin B1 deficiency in SDAT.
ISSN:0248-8663