Pharmaceutical applications of microcalorimetry

General principles and applications of microcalorimetry are reviewed. Microcalorimetry is useful in the study of physical, chemical, and biological drug interactions. The sensitivity of the present instrumentation is approximately 0.1 microW. With this high sensitivity, additional applications have...

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Veröffentlicht in:	Pharmaceutical research 1994-06, Vol.11 (6), p.777-783
1. Verfasser:	KOENIGBAUER, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Calorimetry Chemistry, Pharmaceutical - instrumentation Drug Stability Excipients Food-Drug Interactions General pharmacology Humans Medical sciences Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	General principles and applications of microcalorimetry are reviewed. Microcalorimetry is useful in the study of physical, chemical, and biological drug interactions. The sensitivity of the present instrumentation is approximately 0.1 microW. With this high sensitivity, additional applications have been developed, including the interactions of drugs with food, lymphoma cells, microorganisms, blood, excipients, and cyclodextrin. A recent application of microcalorimetry is the measurement of degradation rates of drugs.
ISSN:	0724-8741 1573-904X
DOI:	10.1023/a:1018957103417