Hypoplasia of G cells in long term steroid-treated rats after ultra-high dose of salmon calcitonin

Male young adult Wistar rats were treated parenterally with cortisol and cortisol combined with salmon calcitonin for 28 and 56 days and the stomach was investigated histologically as well as the G cells using immunohistochemistry. After 28 days of cortisol administration desquamation of the superfi...

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Veröffentlicht in:	Acta histochemica 1994-12, Vol.96 (4), p.379
Hauptverfasser:	Orlicz-Szczesna, G, Jabłoński, M, Gorzelak, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcitonin - administration & dosage Calcitonin - pharmacology Calcitonin - toxicity Disease Models, Animal Drug Interactions Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastrins - biosynthesis Hydrocortisone - administration & dosage Hydrocortisone - pharmacology Hydrocortisone - toxicity Immunohistochemistry Injections, Intraperitoneal Male Rats Rats, Wistar Stomach Ulcer - chemically induced
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Zusammenfassung:	Male young adult Wistar rats were treated parenterally with cortisol and cortisol combined with salmon calcitonin for 28 and 56 days and the stomach was investigated histologically as well as the G cells using immunohistochemistry. After 28 days of cortisol administration desquamation of the superficial layers of gastric mucosa was found and after 56 days ulcer-like changes developed and increased gastrin immunoreactivity was observed. Administration of high doses of salmon calcitonin together with cortisol resulted in a significant hypoplasia of G cells and prevented the pathological changes in the gastric mucosa.
ISSN:	0065-1281