Is the beneficial effect of calcium channel blockers against cyclosporine a toxicity related to a restoration of ATP synthesis ?
ATP synthesis inhibited by Cyclosporine A is restored by calcium channel blockers: nifedipine, verapamil, bepridil, diltiazem. ATP synthesis was estimated using liver mitochondria by measuring the rate of respiration during state 3 and a measure of the yield of ATP synthesis, the P/O ratio. The stud...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical research 1995-04, Vol.12 (4), p.518-522 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 522 |
|---|---|
| container_issue | 4 |
| container_start_page | 518 |
| container_title | Pharmaceutical research |
| container_volume | 12 |
| creator | SALDUCCI, M. D CHAUVET-MONGES, A. M DUSSOL, B. M BERLAND, Y. F CREVAT, A. D |
| description | ATP synthesis inhibited by Cyclosporine A is restored by calcium channel blockers: nifedipine, verapamil, bepridil, diltiazem. ATP synthesis was estimated using liver mitochondria by measuring the rate of respiration during state 3 and a measure of the yield of ATP synthesis, the P/O ratio. The study of calcium fluxes through mitochondrial membrane indicates that calcium channel blockers counteract the mitochondrial calcium storage induced by cyclosporine A. If the restoration of ATP synthesis observed in vitro also occurred in vivo, the increase in ATP pool might contribute to a better functioning of the Ca2+ extrusion pumps of the cells, thereby maintaining the cytosolic calcium concentration (Cai), in the normal range. The nephrotoxicity of cyclosporine A appears to be due to a vasoconstrictive effect related to an increased Cai. This result may account for the reduction of clinical cyclosporine A toxicity by calcium channel blockers. Verapamil appears to be the most efficient in restoring ATP synthesis. |
| doi_str_mv | 10.1023/A:1016293627487 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_7596986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>7596986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-e22089173319cead91566684fa5b744014273cd1a3cc122379d773e9224d348e3</originalsourceid><addsrcrecordid>eNo9kM1LAzEUxIMotVbPnoQcvK7mazeJFynFj0JBDxW8ldfsW41usyVJwb35p7ti8TQw8_g9Zgg55-yKMyGvpzec8UpYWQmtjD4gY15qWVimXg_JmGmhCqMVPyYnKX0wxgy3akRGurSVNdWYfM8Tze9I1xiw8c5DS7Fp0GXaNdRB6_xuQ907hIAtXbed-8SYKLyBDylT17u2S9su-oAUaO6-BkTuacQWMtaDMbgRU-4iZN-FX-h0-UxTH4anySd6e0qOGmgTnu11Ql7u75azx2Lx9DCfTReFE4bnAoVgxnItJbcOoba8rKrKqAbKtVaKcSW0dDUH6RwXQmpbay3RCqFqqQzKCbn442536w3Wq230G4j9ar_EkF_uc0hD7yZCcD79n8lSlNwY-QPtwW1f</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Is the beneficial effect of calcium channel blockers against cyclosporine a toxicity related to a restoration of ATP synthesis ?</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>SALDUCCI, M. D ; CHAUVET-MONGES, A. M ; DUSSOL, B. M ; BERLAND, Y. F ; CREVAT, A. D</creator><creatorcontrib>SALDUCCI, M. D ; CHAUVET-MONGES, A. M ; DUSSOL, B. M ; BERLAND, Y. F ; CREVAT, A. D</creatorcontrib><description>ATP synthesis inhibited by Cyclosporine A is restored by calcium channel blockers: nifedipine, verapamil, bepridil, diltiazem. ATP synthesis was estimated using liver mitochondria by measuring the rate of respiration during state 3 and a measure of the yield of ATP synthesis, the P/O ratio. The study of calcium fluxes through mitochondrial membrane indicates that calcium channel blockers counteract the mitochondrial calcium storage induced by cyclosporine A. If the restoration of ATP synthesis observed in vitro also occurred in vivo, the increase in ATP pool might contribute to a better functioning of the Ca2+ extrusion pumps of the cells, thereby maintaining the cytosolic calcium concentration (Cai), in the normal range. The nephrotoxicity of cyclosporine A appears to be due to a vasoconstrictive effect related to an increased Cai. This result may account for the reduction of clinical cyclosporine A toxicity by calcium channel blockers. Verapamil appears to be the most efficient in restoring ATP synthesis.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1016293627487</identifier><identifier>PMID: 7596986</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Adenosine Triphosphate - biosynthesis ; Animals ; Biological and medical sciences ; Calcium - metabolism ; Calcium Channel Blockers - pharmacology ; Cyclosporine - toxicity ; Drug toxicity and drugs side effects treatment ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar</subject><ispartof>Pharmaceutical research, 1995-04, Vol.12 (4), p.518-522</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-e22089173319cead91566684fa5b744014273cd1a3cc122379d773e9224d348e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3525188$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7596986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALDUCCI, M. D</creatorcontrib><creatorcontrib>CHAUVET-MONGES, A. M</creatorcontrib><creatorcontrib>DUSSOL, B. M</creatorcontrib><creatorcontrib>BERLAND, Y. F</creatorcontrib><creatorcontrib>CREVAT, A. D</creatorcontrib><title>Is the beneficial effect of calcium channel blockers against cyclosporine a toxicity related to a restoration of ATP synthesis ?</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>ATP synthesis inhibited by Cyclosporine A is restored by calcium channel blockers: nifedipine, verapamil, bepridil, diltiazem. ATP synthesis was estimated using liver mitochondria by measuring the rate of respiration during state 3 and a measure of the yield of ATP synthesis, the P/O ratio. The study of calcium fluxes through mitochondrial membrane indicates that calcium channel blockers counteract the mitochondrial calcium storage induced by cyclosporine A. If the restoration of ATP synthesis observed in vitro also occurred in vivo, the increase in ATP pool might contribute to a better functioning of the Ca2+ extrusion pumps of the cells, thereby maintaining the cytosolic calcium concentration (Cai), in the normal range. The nephrotoxicity of cyclosporine A appears to be due to a vasoconstrictive effect related to an increased Cai. This result may account for the reduction of clinical cyclosporine A toxicity by calcium channel blockers. Verapamil appears to be the most efficient in restoring ATP synthesis.</description><subject>Adenosine Triphosphate - biosynthesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cyclosporine - toxicity</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LAzEUxIMotVbPnoQcvK7mazeJFynFj0JBDxW8ldfsW41usyVJwb35p7ti8TQw8_g9Zgg55-yKMyGvpzec8UpYWQmtjD4gY15qWVimXg_JmGmhCqMVPyYnKX0wxgy3akRGurSVNdWYfM8Tze9I1xiw8c5DS7Fp0GXaNdRB6_xuQ907hIAtXbed-8SYKLyBDylT17u2S9su-oAUaO6-BkTuacQWMtaDMbgRU-4iZN-FX-h0-UxTH4anySd6e0qOGmgTnu11Ql7u75azx2Lx9DCfTReFE4bnAoVgxnItJbcOoba8rKrKqAbKtVaKcSW0dDUH6RwXQmpbay3RCqFqqQzKCbn442536w3Wq230G4j9ar_EkF_uc0hD7yZCcD79n8lSlNwY-QPtwW1f</recordid><startdate>19950401</startdate><enddate>19950401</enddate><creator>SALDUCCI, M. D</creator><creator>CHAUVET-MONGES, A. M</creator><creator>DUSSOL, B. M</creator><creator>BERLAND, Y. F</creator><creator>CREVAT, A. D</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19950401</creationdate><title>Is the beneficial effect of calcium channel blockers against cyclosporine a toxicity related to a restoration of ATP synthesis ?</title><author>SALDUCCI, M. D ; CHAUVET-MONGES, A. M ; DUSSOL, B. M ; BERLAND, Y. F ; CREVAT, A. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-e22089173319cead91566684fa5b744014273cd1a3cc122379d773e9224d348e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenosine Triphosphate - biosynthesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cyclosporine - toxicity</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SALDUCCI, M. D</creatorcontrib><creatorcontrib>CHAUVET-MONGES, A. M</creatorcontrib><creatorcontrib>DUSSOL, B. M</creatorcontrib><creatorcontrib>BERLAND, Y. F</creatorcontrib><creatorcontrib>CREVAT, A. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALDUCCI, M. D</au><au>CHAUVET-MONGES, A. M</au><au>DUSSOL, B. M</au><au>BERLAND, Y. F</au><au>CREVAT, A. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the beneficial effect of calcium channel blockers against cyclosporine a toxicity related to a restoration of ATP synthesis ?</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1995-04-01</date><risdate>1995</risdate><volume>12</volume><issue>4</issue><spage>518</spage><epage>522</epage><pages>518-522</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>ATP synthesis inhibited by Cyclosporine A is restored by calcium channel blockers: nifedipine, verapamil, bepridil, diltiazem. ATP synthesis was estimated using liver mitochondria by measuring the rate of respiration during state 3 and a measure of the yield of ATP synthesis, the P/O ratio. The study of calcium fluxes through mitochondrial membrane indicates that calcium channel blockers counteract the mitochondrial calcium storage induced by cyclosporine A. If the restoration of ATP synthesis observed in vitro also occurred in vivo, the increase in ATP pool might contribute to a better functioning of the Ca2+ extrusion pumps of the cells, thereby maintaining the cytosolic calcium concentration (Cai), in the normal range. The nephrotoxicity of cyclosporine A appears to be due to a vasoconstrictive effect related to an increased Cai. This result may account for the reduction of clinical cyclosporine A toxicity by calcium channel blockers. Verapamil appears to be the most efficient in restoring ATP synthesis.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>7596986</pmid><doi>10.1023/A:1016293627487</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-8741 |
| ispartof | Pharmaceutical research, 1995-04, Vol.12 (4), p.518-522 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_pubmed_primary_7596986 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenosine Triphosphate - biosynthesis Animals Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Cyclosporine - toxicity Drug toxicity and drugs side effects treatment Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Rats Rats, Wistar |
| title | Is the beneficial effect of calcium channel blockers against cyclosporine a toxicity related to a restoration of ATP synthesis ? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T00%3A47%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20the%20beneficial%20effect%20of%20calcium%20channel%20blockers%20against%20cyclosporine%20a%20toxicity%20related%20to%20a%20restoration%20of%20ATP%20synthesis%20?&rft.jtitle=Pharmaceutical%20research&rft.au=SALDUCCI,%20M.%20D&rft.date=1995-04-01&rft.volume=12&rft.issue=4&rft.spage=518&rft.epage=522&rft.pages=518-522&rft.issn=0724-8741&rft.eissn=1573-904X&rft.coden=PHREEB&rft_id=info:doi/10.1023/A:1016293627487&rft_dat=%3Cpubmed_pasca%3E7596986%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7596986&rfr_iscdi=true |