Synthesis and anti-inflammatory activity of certain new N,N'-oxamides
Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing r...
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| Veröffentlicht in: | Pharmazie 1980, Vol.35 (7), p.394 |
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| container_title | Pharmazie |
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| creator | Abdel-Aleem, A M Abdel-Kader, M A El-Koussi, A A |
| description | Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested. |
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The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 7413710</identifier><language>eng</language><publisher>Germany</publisher><subject>Amino Acids - chemical synthesis ; Animals ; Anti-Inflammatory Agents - chemical synthesis ; Anti-Inflammatory Agents - toxicity ; Aspirin - pharmacology ; Female ; Histamine ; Inflammation - chemically induced ; Lethal Dose 50 ; Male ; Oxamic Acid - analogs & derivatives ; Oxamic Acid - chemical synthesis ; Oxamic Acid - pharmacology ; Oxamic Acid - toxicity ; Rats ; Xylenes</subject><ispartof>Pharmazie, 1980, Vol.35 (7), p.394</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7413710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Aleem, A M</creatorcontrib><creatorcontrib>Abdel-Kader, M A</creatorcontrib><creatorcontrib>El-Koussi, A A</creatorcontrib><title>Synthesis and anti-inflammatory activity of certain new N,N'-oxamides</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. 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The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested.</abstract><cop>Germany</cop><pmid>7413710</pmid></addata></record> |
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| identifier | ISSN: 0031-7144 |
| ispartof | Pharmazie, 1980, Vol.35 (7), p.394 |
| issn | 0031-7144 |
| language | eng |
| recordid | cdi_pubmed_primary_7413710 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amino Acids - chemical synthesis Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - toxicity Aspirin - pharmacology Female Histamine Inflammation - chemically induced Lethal Dose 50 Male Oxamic Acid - analogs & derivatives Oxamic Acid - chemical synthesis Oxamic Acid - pharmacology Oxamic Acid - toxicity Rats Xylenes |
| title | Synthesis and anti-inflammatory activity of certain new N,N'-oxamides |
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