Synthesis and anti-inflammatory activity of certain new N,N'-oxamides

Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing r...

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Veröffentlicht in:	Pharmazie 1980, Vol.35 (7), p.394
Hauptverfasser:	Abdel-Aleem, A M, Abdel-Kader, M A, El-Koussi, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemical synthesis Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - toxicity Aspirin - pharmacology Female Histamine Inflammation - chemically induced Lethal Dose 50 Male Oxamic Acid - analogs & derivatives Oxamic Acid - chemical synthesis Oxamic Acid - pharmacology Oxamic Acid - toxicity Rats Xylenes
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Zusammenfassung:	Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested.
ISSN:	0031-7144