Co-carcinogenicity of promoting agents

An experiment is described to investigate whether coadministration of a promoting agent would enhance the carcinogenicity of a repeatedly administered complete carcinogen. Topical application of the strong carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one (I) in toluene containing 1%...

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Veröffentlicht in:	Carcinogenesis (N.Y.); (United States) 1981, Vol.2 (7), p.687
Hauptverfasser:	Vose, C W, Coombs, M M, Bhatt, T S
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ANIMALS AROMATICS BENZOPYRENE BIOLOGICAL EFFECTS BODY CARCINOGEN SCREENING CARCINOGENESIS Carcinogens - pharmacology Cocarcinogenesis CONDENSED AROMATICS CROTON OIL Croton Oil - toxicity Environmental Pollutants - toxicity ESTERS Female Gonanes - toxicity HYDROCARBONS LIPIDS Male MAMMALS MICE OILS ORGANIC COMPOUNDS ORGANS OTHER ORGANIC COMPOUNDS PATHOGENESIS PHENANTHRENE PROMOTERS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RODENTS SCREENING SENSITIVITY SKIN TOLUENE TRIGLYCERIDES TUMOR PROMOTERS VERTEBRATES
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Beschreibung
Zusammenfassung:	An experiment is described to investigate whether coadministration of a promoting agent would enhance the carcinogenicity of a repeatedly administered complete carcinogen. Topical application of the strong carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one (I) in toluene containing 1% v/v croton oil is about five times more effective than applications in toluene alone, as judged from the respective mean latent periods. A similar effect is also apparent for benzo[a]pyrene.
ISSN:	0143-3334
DOI:	10.1093/carcin/2.7.687