The Pharmacokinetics of Prunasin, a Metabolite of Amygdalin

The Pharmacokinetics of Prunasin, a Metabolite of Amygdalin

Abstract The pharmacokinetics of prunasin have been investigated in the dog. The results are compared with results obtained with amygdalin. The volume of distribution and the clearance of prunasin are larger than those of amygdalin. The oral bioavailability of prunasin is approximately 50%, whereas...

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Veröffentlicht in:Clinical toxicology (Philadelphia, Pa.) Pa.), 1982, Vol.19 (8), p.851-856
Hauptverfasser: Rauws, A. G., Olling, M., Timmerman, A.
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Amygdalin - blood
Amygdalin - metabolism
Animals
Biological Availability
Dogs
Half-Life
Injections, Intravenous
Kinetics
Nitriles - blood
Nitriles - metabolism
Tissue Distribution
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Zusammenfassung:Abstract The pharmacokinetics of prunasin have been investigated in the dog. The results are compared with results obtained with amygdalin. The volume of distribution and the clearance of prunasin are larger than those of amygdalin. The oral bioavailability of prunasin is approximately 50%, whereas amygdalin is hardly absorbed unchanged.
ISSN:1556-3650
0731-3810
1556-9519
DOI:10.3109/15563658208992518