Effect of dietary protein and lipid on the activity of hepatic mixed-function oxidase system in young and adult rats

Effects of marginal or normal casein diets with different sunflower oil contents were tested on the hepatic mixed-function oxidase system in young and adult male rats. The weight gain and the activity of aminopyrine demethylase, aniline hydroxylase and the content of cytochrome P-450 was decreased only in young rats fed 10% casein and 10% oil containing diets. Both in young and adult animals, independently of casein consumption, the activity of MFO with the exception of cytochrome P-450 in adult rats fed 20% casein was significantly higher when the level of dietary sunflower oil was shifted from 10 to 30%.