Inhibition of Partial Closure of Epiphyseal Plate in Rabbits by Indomethacin

The efficiency of indomethacin (10 mg/kg/day) in inhibiting recurrent partial closure of the epiphyseal plate was tested in rabbits. An epiphysiodesis was done laterally in the distal left femoral epiphyseal plate in 19 adolescent rabbits. This produced a valgus deformity in 14 of them. The bone bri...

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Veröffentlicht in:Acta orthopaedica 1982-01, Vol.53 (4), p.507-511
Hauptverfasser: Sudmann, Einar, Husby, Otto Schnell, Bang, Gisle
Format: Artikel
Sprache:eng
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Zusammenfassung:The efficiency of indomethacin (10 mg/kg/day) in inhibiting recurrent partial closure of the epiphyseal plate was tested in rabbits. An epiphysiodesis was done laterally in the distal left femoral epiphyseal plate in 19 adolescent rabbits. This produced a valgus deformity in 14 of them. The bone bridge was then removed operatively and the rabbits were treated with either indomethacin or vehicle for 21 days postoperatively. Indomethacin plasma levels were about 180 ng/ml. The valgus deformity improved in indomethacin-treated rabbits, whereas it became worse in the controls (P = 0.004).
ISSN:1745-3674
0001-6470
1745-3682
DOI:10.3109/17453678208992249