CYTOSTATIC ACTION OF HUMAN FIBROBLAST INTERFERON IN DIRECT GROWTH INHIBITION: EFFECT ON HUMAN MALIGNANT MELANOMA

The mode of action of the direct antiproliferative effect of human fibroblast interferon (HuIFN-β) on tumor cells was analyzed in vitro with a human malignant melanoma cell line, HMV-1. HuIFN-β inhibited the growth of HMV-1 cells in a time-dependent fashion (50%-inhibition concentration:

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Bibliographische Detailangaben
Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1983, Vol.74(3), pp.452-458
Hauptverfasser:	NAGAO, Shin'ichi, TOHGO, Akiko, KOHNO, Morihiro, OGAWA, Hidemasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Cycle - drug effects Cell Line Chemotherapy DNA, Neoplasm - biosynthesis Human fibroblast interferon (HuIFN-β) Human malignant melanoma Humans Interferon Type I - therapeutic use Medical sciences Melanoma - metabolism Melanoma - therapy Mode of action Neoplasm Proteins - biosynthesis Pharmacology. Drug treatments RNA, Neoplasm - biosynthesis
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Beschreibung
Zusammenfassung:	The mode of action of the direct antiproliferative effect of human fibroblast interferon (HuIFN-β) on tumor cells was analyzed in vitro with a human malignant melanoma cell line, HMV-1. HuIFN-β inhibited the growth of HMV-1 cells in a time-dependent fashion (50%-inhibition concentration:
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.74.3_452