TRANSPLANTABLE CHORIOCARCINOMA OF RATS INDUCED BY FETECTOMY AND ITS BIOLOGICAL ACTIVITIES
Eight cases of choriocarcinoma were induced in WKA female rats by simple fetectomy without viral inoculation or administration of chemical carcinogens. Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. T...
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| Veröffentlicht in: | GANN Japanese Journal of Cancer Research 1983, Vol.74(2), pp.205-212 |
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| container_issue | 2 |
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| container_title | GANN Japanese Journal of Cancer Research |
| container_volume | 74 |
| creator | TESHIMA, Shinichi SHIMOSATO, Yukio KOIDE, Tsutomu KUROKI, Masahito KIKUCHI, Yuko AIZAWA, Miki |
| description | Eight cases of choriocarcinoma were induced in WKA female rats by simple fetectomy without viral inoculation or administration of chemical carcinogens. Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. The histological appearance of RCHO consisted of trophoblastic giant cells and small basophilic tumor cells, which resembled normal rat placenta. RCHO possessed marked mammotropic and lactogenic activities in female recipients and induced atrophy of the testes in male recipients. |
| doi_str_mv | 10.20772/cancersci1959.74.2_205 |
| format | Article |
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Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. The histological appearance of RCHO consisted of trophoblastic giant cells and small basophilic tumor cells, which resembled normal rat placenta. RCHO possessed marked mammotropic and lactogenic activities in female recipients and induced atrophy of the testes in male recipients.</description><identifier>ISSN: 0016-450X</identifier><identifier>DOI: 10.20772/cancersci1959.74.2_205</identifier><identifier>PMID: 6683207</identifier><language>eng</language><publisher>Tokyo: The Japanese Cancer Association</publisher><subject>Animals ; Biological and medical sciences ; Cell Line ; Choriocarcinoma ; Choriocarcinoma - etiology ; Choriocarcinoma - pathology ; Diseases of mother, fetus and pregnancy ; Female ; Fetectomy ; Fetus - physiology ; Gynecology. Andrology. Obstetrics ; Medical sciences ; Neoplasm Transplantation ; Neoplasms, Experimental - etiology ; Neoplasms, Experimental - pathology ; Placental lactogen ; Placental Lactogen - biosynthesis ; Pregnancy ; Pregnancy. Fetus. Placenta ; Rat ; Rats ; Rats, Inbred Strains ; Transplantation ; Uterine Neoplasms - etiology ; Uterine Neoplasms - pathology</subject><ispartof>GANN Japanese Journal of Cancer Research, 1983, Vol.74(2), pp.205-212</ispartof><rights>The Japanese Cancer Association</rights><rights>1984 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9573115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6683207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TESHIMA, Shinichi</creatorcontrib><creatorcontrib>SHIMOSATO, Yukio</creatorcontrib><creatorcontrib>KOIDE, Tsutomu</creatorcontrib><creatorcontrib>KUROKI, Masahito</creatorcontrib><creatorcontrib>KIKUCHI, Yuko</creatorcontrib><creatorcontrib>AIZAWA, Miki</creatorcontrib><title>TRANSPLANTABLE CHORIOCARCINOMA OF RATS INDUCED BY FETECTOMY AND ITS BIOLOGICAL ACTIVITIES</title><title>GANN Japanese Journal of Cancer Research</title><addtitle>GANN Japanese Journal of Cancer Research</addtitle><description>Eight cases of choriocarcinoma were induced in WKA female rats by simple fetectomy without viral inoculation or administration of chemical carcinogens. Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. The histological appearance of RCHO consisted of trophoblastic giant cells and small basophilic tumor cells, which resembled normal rat placenta. RCHO possessed marked mammotropic and lactogenic activities in female recipients and induced atrophy of the testes in male recipients.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Choriocarcinoma</subject><subject>Choriocarcinoma - etiology</subject><subject>Choriocarcinoma - pathology</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetectomy</subject><subject>Fetus - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Medical sciences</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - etiology</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Placental lactogen</subject><subject>Placental Lactogen - biosynthesis</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Transplantation</subject><subject>Uterine Neoplasms - etiology</subject><subject>Uterine Neoplasms - pathology</subject><issn>0016-450X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1vwjAQhj20oojyE6p66Brq2PFHRhNCsRSSKoSqTJHjOG0QoCqhQ_99LRFR9Ya74XnupHsBePTRDCPO8bPRJ2O73rR-SMMZD2a4xIjegDFCPvMCit7vwLTv98gVwxxzNgIjxgRx62OwK3KZbl4TmRZynsQwWmW5yiKZRyrN1hJmS5jLYgNVuthG8QLOd3AZF3FUZOsdlOkCKgfnKkuyFxXJBMqoUG-qUPHmHtw2-tDb6TAnYOs2o5U3qN4-CMKzV2suBOMEB9YawylB3GhLtUDUWFPXTITUZ1XFhWkCbSrqCytIFTbYcIGJIBPwcLn79V0dbV1-de1Rdz_l8KLjTwPXvdGHpnN5tf1VCyknvk-dpi7avj_rD3vluju35mDLfzGXPCjxpbms_5xP3ZX2RH4BlZ10dA</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>TESHIMA, Shinichi</creator><creator>SHIMOSATO, Yukio</creator><creator>KOIDE, Tsutomu</creator><creator>KUROKI, Masahito</creator><creator>KIKUCHI, Yuko</creator><creator>AIZAWA, Miki</creator><general>The Japanese Cancer Association</general><general>Japan Publications Trading</general><general>Japanese Cancer Association</general><general>Cancer Institute</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19830101</creationdate><title>TRANSPLANTABLE CHORIOCARCINOMA OF RATS INDUCED BY FETECTOMY AND ITS BIOLOGICAL ACTIVITIES</title><author>TESHIMA, Shinichi ; SHIMOSATO, Yukio ; KOIDE, Tsutomu ; KUROKI, Masahito ; KIKUCHI, Yuko ; AIZAWA, Miki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j449t-da78867324eecc75307cae5a805cecdd689516bb78cf4acb518e83b9f2c782383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Choriocarcinoma</topic><topic>Choriocarcinoma - etiology</topic><topic>Choriocarcinoma - pathology</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetectomy</topic><topic>Fetus - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Medical sciences</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - etiology</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Placental lactogen</topic><topic>Placental Lactogen - biosynthesis</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Transplantation</topic><topic>Uterine Neoplasms - etiology</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>TESHIMA, Shinichi</creatorcontrib><creatorcontrib>SHIMOSATO, Yukio</creatorcontrib><creatorcontrib>KOIDE, Tsutomu</creatorcontrib><creatorcontrib>KUROKI, Masahito</creatorcontrib><creatorcontrib>KIKUCHI, Yuko</creatorcontrib><creatorcontrib>AIZAWA, Miki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>GANN Japanese Journal of Cancer Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TESHIMA, Shinichi</au><au>SHIMOSATO, Yukio</au><au>KOIDE, Tsutomu</au><au>KUROKI, Masahito</au><au>KIKUCHI, Yuko</au><au>AIZAWA, Miki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRANSPLANTABLE CHORIOCARCINOMA OF RATS INDUCED BY FETECTOMY AND ITS BIOLOGICAL ACTIVITIES</atitle><jtitle>GANN Japanese Journal of Cancer Research</jtitle><addtitle>GANN Japanese Journal of Cancer Research</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>74</volume><issue>2</issue><spage>205</spage><epage>212</epage><pages>205-212</pages><issn>0016-450X</issn><abstract>Eight cases of choriocarcinoma were induced in WKA female rats by simple fetectomy without viral inoculation or administration of chemical carcinogens. Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. The histological appearance of RCHO consisted of trophoblastic giant cells and small basophilic tumor cells, which resembled normal rat placenta. RCHO possessed marked mammotropic and lactogenic activities in female recipients and induced atrophy of the testes in male recipients.</abstract><cop>Tokyo</cop><pub>The Japanese Cancer Association</pub><pmid>6683207</pmid><doi>10.20772/cancersci1959.74.2_205</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-450X |
| ispartof | GANN Japanese Journal of Cancer Research, 1983, Vol.74(2), pp.205-212 |
| issn | 0016-450X |
| language | eng |
| recordid | cdi_pubmed_primary_6683207 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Biological and medical sciences Cell Line Choriocarcinoma Choriocarcinoma - etiology Choriocarcinoma - pathology Diseases of mother, fetus and pregnancy Female Fetectomy Fetus - physiology Gynecology. Andrology. Obstetrics Medical sciences Neoplasm Transplantation Neoplasms, Experimental - etiology Neoplasms, Experimental - pathology Placental lactogen Placental Lactogen - biosynthesis Pregnancy Pregnancy. Fetus. Placenta Rat Rats Rats, Inbred Strains Transplantation Uterine Neoplasms - etiology Uterine Neoplasms - pathology |
| title | TRANSPLANTABLE CHORIOCARCINOMA OF RATS INDUCED BY FETECTOMY AND ITS BIOLOGICAL ACTIVITIES |
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