TRANSPLANTABLE CHORIOCARCINOMA OF RATS INDUCED BY FETECTOMY AND ITS BIOLOGICAL ACTIVITIES

Eight cases of choriocarcinoma were induced in WKA female rats by simple fetectomy without viral inoculation or administration of chemical carcinogens. Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. T...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1983, Vol.74(2), pp.205-212
Hauptverfasser:	TESHIMA, Shinichi, SHIMOSATO, Yukio, KOIDE, Tsutomu, KUROKI, Masahito, KIKUCHI, Yuko, AIZAWA, Miki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Choriocarcinoma Choriocarcinoma - etiology Choriocarcinoma - pathology Diseases of mother, fetus and pregnancy Female Fetectomy Fetus - physiology Gynecology. Andrology. Obstetrics Medical sciences Neoplasm Transplantation Neoplasms, Experimental - etiology Neoplasms, Experimental - pathology Placental lactogen Placental Lactogen - biosynthesis Pregnancy Pregnancy. Fetus. Placenta Rat Rats Rats, Inbred Strains Transplantation Uterine Neoplasms - etiology Uterine Neoplasms - pathology
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Zusammenfassung:	Eight cases of choriocarcinoma were induced in WKA female rats by simple fetectomy without viral inoculation or administration of chemical carcinogens. Among them, one line has been successfully subcutaneously transplanted over 10 generations in syngeneic rats and this line was designated as RCHO. The histological appearance of RCHO consisted of trophoblastic giant cells and small basophilic tumor cells, which resembled normal rat placenta. RCHO possessed marked mammotropic and lactogenic activities in female recipients and induced atrophy of the testes in male recipients.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.74.2_205